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Stability and folding of G-protein coupled receptors associated to degenerative diseases

Dong, Xiaoyun (Date of defense: 2016-05-25)

G-protein coupled receptors (GPCRs) are the largest membrane protein superfamily encoded by the human genome and represent the largest class of drug targets for a wide range of pathological conditions. ...

Stability and ligand binding properties of human cone visual pigments

Srinivasan, Sundaramoorthy (Date of defense: 2015-10-02)

Human color perception is mediated by cone photoreceptor cells which mainly locate on the fovea of the eye. Bright light activates the photosensitive opsin pigments which are embedded in the outer segment ...