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Structure-activity investigation on laccases by computational and site directed mutagenesis studies

Delavari, Azar (Date of defense: 01-12-2016)
Laccases belong to multi copper oxidase enzyme family (EC 1.10.3.2). Their capacity to oxidíze a wide range of substrates makes them very attractive for the industry and are growing in importance for environmentally-friendly ...
Discovery of new selective antagonists of G-protein coupled receptors of therapeutic interest

Lupala, Cecylia Severin (Date of defense: 28-01-2016)
GPCR are integral membrane receptor proteins that are characterized by heptahelical transmembrane domains connected by intracellular and extracellular loops. GPCRs are an attractive class of proteins for drug discovery, ...