Ara mostrant els elements 417-436 de 459

    Study of radiotherapy resistance associated to EGFR/MAPK signaling pathway and its application in the rational design of a treatment with simvastatin in combination with cetuximab and radiotherapy (in experimental models of carcinoma) 

    Llobet Cucalón, Lara Isabel de (Data de defensa: 2013-11-22)

    1. Generation and characterization of a radioresistant cell line In the first part of this project of Thesis, we subjected culture cells to fractionated radiation and clonal selection, to obtain a modified cohort of ...

    Study of the expression and regulation of the autocrine loop components of the cyclooxygenase pathway and their implication in aspirin exacerbated respiratory disease 

    Machado de Carvalho, Liliana Sofia (Data de defensa: 2015-11-27)

    Aspirin exacerbated respiratory disease (AERD) is a clinical syndrome characterized by the combination of nasal polyps (NPs), chronic hypertrophic eosinophilic sinusitis, asthma and severity to any medication that inhibits ...

    Surgical Assessment of Insular Gliomas: Operative Technique and Clinical Outcomes 

    Benet Cabero, Arnau (Data de defensa: 2020-11-09)

    BACKGROUND: Surgical treatment of Insular gliomas is technically challenging and may lead to high postoperative morbidity. However, previous research has proven that maximal safe resection is critical for ...

    Susceptibilidad a Melanoma: nuevos aspectos clínico-patológicos, desarrollo de herramientas y modelos de estudio y evaluación de medidas preventivas 

    Aguilera Peiró, Paula (Data de defensa: 2015-09-23)

    El trabajo contenido en esta Tesis Doctoral ha ido encaminado a mejorar el conocimiento del Melanoma Familiar con el fin de mejorar su prevención y tratamiento. En el primero de los trabajos publicados se han descrito y ...

    Susceptibilidad genética al cáncer gástrico y lesiones precursoras, y mecanismos moleculares que intervienen en la progresión de la metaplasia intestinal 

    Companioni Nápoles, Osmel (Data de defensa: 2015-10-26)

    El cáncer gástrico es el resultado de sucesivos cambios histológicos en la mucosa gástrica conocidos como lesiones preneoplásicas y cuya sucesión es conocida como la Cascada de Correa, constituyendo el mecanismo de ...

    Synaptic and non-synaptic propagation of slow waves and their modulation by endogenous electric fields 

    Rebollo González, Beatriz (Data de defensa: 2017-06-14)

    The cerebral cortex is organized in complex circuits of neurons strongly interconnected in a conductive medium. During deep sleep stage, this neuronal connectivity generates recurrent synchronized synaptic activity leading ...

    Synthesis and biological function of fucose in Plasmodium falciparum 

    Sanz Sender, Silvia (Data de defensa: 2017-04-28)

    Malaria is a parasitic disease caused by Plasmodium parasites and it is transmitted by female Anopheles mosquito. P. falciparum has a complex life cycle that includes important stages in two different hosts: a mosquito and ...

    A Systems Medicine approach to multimorbidity. Towards personalised care for patients with Chronic Obstructive Pulmonary Disease 

    Tényi, Ákos (Data de defensa: 2018-07-13)

    BACKGROUND: Multimorbidity (i.e. the presence of more than one chronic disease in the same patient) and comorbidity (i.e. the presence of more than one chronic disease in the presence of an index disease) are main sources ...

    Target Therapy in Rhabdomyosarcoma: Discovering new targets and apportunities 

    Prada Varela, Estela Maria (Data de defensa: 2021-11-05)

    Pediatric RMS is a developmental tumor that affects patients from birth to late adolescence. RMS tumorigenesis involves the stalk of embryological myogenic processes. Classically, two main subgroups of RMS have been defined ...

    Targeted therapies in CLL. New drugs against CLL recurrent mutations 

    Giménez Carabaza, Neus (Data de defensa: 2019-11-15)

    Chronic lymphocytic leukemia (CLL) is the most common leukemia in the western countries. It is currently an incurable disease. CLL is a B-lymphoid neoplasm in which the microenvironment plays a key role in the development ...

    Targeting Malaria Transmission: A Transdisciplinary Approach 

    Portugaliza, Harvie P. (Data de defensa: 2020-12-16)

    To achieve malaria elimination, great emphasis must be put on targeting the parasite’s transmissible stages, so that along with effective treatment of clinical malaria caused by asexual stages, complete interruption of the ...

    Targeting the crosstalk between tumor cells and microenvironment: a new therapeutic approach for the treatment of lymphoid neoplasms 

    Vidal Crespo, Anna (Data de defensa: 2017-04-28)

    In this thesis we have focused on two novel therapeutic strategies that target the crosstalk between the tumor cells and the microenvironment. Chronic lymphocytic leukemia (CLL) remains an incurable disease where high ...

    Targeting tumor microenvironment crosstalk through GPCR receptors and PI3K pathway 

    Guerrero Hernández, Martina (Data de defensa: 2019-02-19)

    The tumor microenvironment (TME) is gaining momentum due to its contribution to cancer progression and therapy resistance. This TME has a direct crosstalk with tumor cells that involves the activation of different ...

    Tatuaje y delincuencia 

    Font Riera, Gabriel (Data de defensa: 1971-01-01)

    Por el nacimiento y habitual radicación en las Islas Baleares, y en tanto cursamos los estudios preuniversitarios. permitió que durante varios años llamara poderosamente nuestra atención el observar en innumerables ...

    Temperamento y carácter en trastornos de la conducta alimentaria: correlatos clínicos, psicopatológicos y terapéuticos 

    Agüera, Zaida (Data de defensa: 2013-12-12)

    Los Trastornos de la Conducta Alimentaria (TCA) son enfermedades mentales complejas en las que convergen numerosos de factores de riesgo y mantenimiento. La literatura previa pone de relieve la importancia de los rasgos ...

    Teràpia gènica amb hHGF en models de dany renal 

    Franquesa Bartolomé, Marcela (Data de defensa: 2010-01-15)

    La isquèmia renal és una de les principals causes del Fracas Renal Agut i en el context del trasplantament renal predisposa l’òrgan a un dany crònic i a una possible pèrdua de l’empelt. La cèl•lula epitelial tubular ...

    The association of DNA methylation patterns in TCF7L2 and GIPR genes with Type 2 Diabetes 

    Canivell Fusté, Silvia (Data de defensa: 2014-10-14)

    The incidence of type 2 diabetes mellitus (T2D) is increasing worldwide. There are several explanations to this fact, such as the increased prevalence of obesity, population’s ageing, and the lack of physical activity ...

    The dynamics of emotional and cognitive networks: Graph-based analysis of brain networks using fMRI and theoretical model for cingulo-frontal network dynamics in major depression 

    Ramírez Mahaluf, Juan Pablo (Data de defensa: 2015-05-14)

    This thesis is composed of two complementary projects. One focuses on the study of the dynamics between emotional and cognitive networks in healthy subjects using functional magnetic resonance imaging (fMRI). The second ...

    The epidemiology of diarrhea: Determination of the burden, etiology and consequences of diarrheal disease in children aged 0-59 months in Manhiça District, Mozambique = La epidemiología de las diarreas: Determinación del peso, etiología y secuelas de la enfermedad diarreica en niños de 0-59 meses de edad en el Distrito de Manhiça, Mozambique 

    Nhampossa, Tacilta Helena Francisco (Data de defensa: 2013-12-20)

    The objective of this thesis is to improve our understanding of the epidemiology of diarrhea, particularly to estimate the population-based burden, microbiologic etiology and adverse clinical consequences of moderate-to-severe ...

    The possible link between high glucose-induced PKCβ expression and the appearance of GLP-1 resistance in endothelial cells 

    De Nigris, Valeria (Data de defensa: 2015-12-03)

    INTRODUCTION. It has been demonstrated that Glucagon-like peptide-1 (GPL-1) has a protective effect on endothelial cells. GLP-1 improves endothelial function in diabetes, however the mechanisms underlying the GLP-1 protective ...