Now showing items 417-436 of 459
Llobet Cucalón, Lara Isabel de (Date of defense: 2013-11-22)
1. Generation and characterization of a radioresistant cell line In the first part of this project of Thesis, we subjected culture cells to fractionated radiation and clonal selection, to obtain a modified cohort of ...
Machado de Carvalho, Liliana Sofia (Date of defense: 2015-11-27)
Aspirin exacerbated respiratory disease (AERD) is a clinical syndrome characterized by the combination of nasal polyps (NPs), chronic hypertrophic eosinophilic sinusitis, asthma and severity to any medication that inhibits ...
Benet Cabero, Arnau (Date of defense: 2020-11-09)
BACKGROUND: Surgical treatment of Insular gliomas is technically challenging and may lead to high postoperative morbidity. However, previous research has proven that maximal safe resection is critical for ...
Aguilera Peiró, Paula (Date of defense: 2015-09-23)
El trabajo contenido en esta Tesis Doctoral ha ido encaminado a mejorar el conocimiento del Melanoma Familiar con el fin de mejorar su prevención y tratamiento. En el primero de los trabajos publicados se han descrito y ...
Companioni Nápoles, Osmel (Date of defense: 2015-10-26)
El cáncer gástrico es el resultado de sucesivos cambios histológicos en la mucosa gástrica conocidos como lesiones preneoplásicas y cuya sucesión es conocida como la Cascada de Correa, constituyendo el mecanismo de ...
Rebollo González, Beatriz (Date of defense: 2017-06-14)
The cerebral cortex is organized in complex circuits of neurons strongly interconnected in a conductive medium. During deep sleep stage, this neuronal connectivity generates recurrent synchronized synaptic activity leading ...
Sanz Sender, Silvia (Date of defense: 2017-04-28)
Malaria is a parasitic disease caused by Plasmodium parasites and it is transmitted by female Anopheles mosquito. P. falciparum has a complex life cycle that includes important stages in two different hosts: a mosquito and ...
Tényi, Ákos (Date of defense: 2018-07-13)
BACKGROUND: Multimorbidity (i.e. the presence of more than one chronic disease in the same patient) and comorbidity (i.e. the presence of more than one chronic disease in the presence of an index disease) are main sources ...
Prada Varela, Estela Maria (Date of defense: 2021-11-05)
Pediatric RMS is a developmental tumor that affects patients from birth to late adolescence. RMS tumorigenesis involves the stalk of embryological myogenic processes. Classically, two main subgroups of RMS have been defined ...
Giménez Carabaza, Neus (Date of defense: 2019-11-15)
Chronic lymphocytic leukemia (CLL) is the most common leukemia in the western countries. It is currently an incurable disease. CLL is a B-lymphoid neoplasm in which the microenvironment plays a key role in the development ...
Portugaliza, Harvie P. (Date of defense: 2020-12-16)
To achieve malaria elimination, great emphasis must be put on targeting the parasite’s transmissible stages, so that along with effective treatment of clinical malaria caused by asexual stages, complete interruption of the ...
Vidal Crespo, Anna (Date of defense: 2017-04-28)
In this thesis we have focused on two novel therapeutic strategies that target the crosstalk between the tumor cells and the microenvironment. Chronic lymphocytic leukemia (CLL) remains an incurable disease where high ...
Guerrero Hernández, Martina (Date of defense: 2019-02-19)
The tumor microenvironment (TME) is gaining momentum due to its contribution to cancer progression and therapy resistance. This TME has a direct crosstalk with tumor cells that involves the activation of different ...
Font Riera, Gabriel (Date of defense: 1971-01-01)
Por el nacimiento y habitual radicación en las Islas Baleares, y en tanto cursamos los estudios preuniversitarios. permitió que durante varios años llamara poderosamente nuestra atención el observar en innumerables ...
Agüera, Zaida (Date of defense: 2013-12-12)
Los Trastornos de la Conducta Alimentaria (TCA) son enfermedades mentales complejas en las que convergen numerosos de factores de riesgo y mantenimiento. La literatura previa pone de relieve la importancia de los rasgos ...
Franquesa Bartolomé, Marcela (Date of defense: 2010-01-15)
La isquèmia renal és una de les principals causes del Fracas Renal Agut i en el context del trasplantament renal predisposa l’òrgan a un dany crònic i a una possible pèrdua de l’empelt. La cèl•lula epitelial tubular ...
Canivell Fusté, Silvia (Date of defense: 2014-10-14)
The incidence of type 2 diabetes mellitus (T2D) is increasing worldwide. There are several explanations to this fact, such as the increased prevalence of obesity, population’s ageing, and the lack of physical activity ...
Ramírez Mahaluf, Juan Pablo (Date of defense: 2015-05-14)
This thesis is composed of two complementary projects. One focuses on the study of the dynamics between emotional and cognitive networks in healthy subjects using functional magnetic resonance imaging (fMRI). The second ...
Nhampossa, Tacilta Helena Francisco (Date of defense: 2013-12-20)
The objective of this thesis is to improve our understanding of the epidemiology of diarrhea, particularly to estimate the population-based burden, microbiologic etiology and adverse clinical consequences of moderate-to-severe ...
De Nigris, Valeria (Date of defense: 2015-12-03)
INTRODUCTION. It has been demonstrated that Glucagon-like peptide-1 (GPL-1) has a protective effect on endothelial cells. GLP-1 improves endothelial function in diabetes, however the mechanisms underlying the GLP-1 protective ...