Computational Studies of the Mechanism of Catalysis and Inhibition of Cysteine Proteases 

Arafet Cruz, Kemel (Date of defense: 2017-09-27)

Falcipain-2 and cruzain are cysteine proteases involve in Malaria and Chagas disease. Today, many aspects of both, inhibition mechanism and catalytic mechanism of these enzymes are unclear. Thus, it is crucial to improve ...