Now showing items 9-28 of 85
Clavero Puyal, Pau (Date of defense: 2016-07-25)
La Tesi tracta sobre la preparació i l’ús en catàlisi homogènia asimètrica de lligands fosforats quirals amb àtoms de fòsfor estereogènics. En primer lloc es descriu la preparació i caracterització de lligands monofosforats ...
Esquivias Bautista de Lisbona, Oriol (Date of defense: 2023-11-17)
[eng] Carbohydrates, as the most abundant biomolecules, play a myriad of roles and functions in biological systems. Unlike the building blocks of proteins, amino acids, whose chemical structure can vary significantly, ...
Alonso Gil, Santiago (Date of defense: 2017-07-12)
Carbohydrates are one of the most important biochemical molecules due to their role as energetic resource for non-photosynthetic organisms, cell-cell recognition and adhesion, protection of cell membranes of bacteria and ...
Faustino Brissos, Rosa Maria (Date of defense: 2018-04-13)
The discovery of cisplatin and its successful use as chemotherapeutic agent have encouraged the development of metal-based anticancer molecules. The present doctoral research project includes three different chemistry ...
Rovira Vidal, Anna (Date of defense: 2023-03-03)
[eng] In this Thesis, we have explored the applications in cancer diagnosis and therapy of COUPY fluorophores, a new family of compounds based on the coumarin structure and operating in the far-red to near infrared region ...
Lázaro Palacios, Ariadna (Date of defense: 2023-05-05)
[eng] This Doctoral Thesis is focused on the synthesis of cyclometallated platinum compounds with different structural modifications rationally designed specifically for biological or optical applications. Specifically, ...
López Barallobre, Blanca (Date of defense: 2016-09-21)
Posar al mercat un nou fàrmac és un procés molt llarg i costós i que comporta un risc econòmic important per una empresa farmacèutica. En canvi, el desenvolupament d'un procediment millorat per a la producció d'un fàrmac ...
Duran Corbera, Macarena (Date of defense: 2021-09-30)
Investigacions recents en el camp de la biomedicina han demostrat que les interaccions entre pèptids i macromolècules com ara les proteïnes, modulen i regulen processos biològics importants com la memòria, la resposta a ...
Borilović, Ivana (Date of defense: 2018-11-23)
Combining the judiciously designed bis−β-diketone and polypyrazolyl scaffolds with the crystal field effects on the 3d metal ions, this manuscript exposes different methods of selective preparation of new heterometallic ...
Salinas Uber, Jorge (Date of defense: 2016-07-29)
One of the main objectives of this thesis was the synthesis of new chelating ligands containing a photochromic unit able to change its conformation upon light irradiation. This isomerization should serve to modify the ...
Bertran Junqué, Alexandra (Date of defense: 2018-10-25)
Matrix metalloproteinases (MMPs) are a family of zinc-containing endopeptidases involved in the degradation of the extracellular matrix. They make a major contribution to the progression of a vast number of diseases, ...
Martínez Bascuñana, Alba (Date of defense: 2023-09-01)
[eng] The use of supramolecular interactions in catalysis has been widely studied and exploited for the straightforward preparation of the backbones of an array of structurally diverse stereoselective catalysts. In addition ...
Dalmases Solé, Mariona (Date of defense: 2019-02-08)
The size/shape dependent and unique physical and chemical properties presented by nanostructured materials have attracted great attention in several fields such as energy harvesting, optoelectronics and biomedicine, among ...
Solé Solé, Judith (Date of defense: 2022-06-03)
Following the laws of evolution, bacteria are capable of slowly but inexorably acquiring resistance to antibiotic compounds that we have been using for decades. Therefore, bacteria that seemed harmless to most people (such ...
Diego Creixenti, Rosa (Date of defense: 2022-01-21)
Spin crossover (SCO) complexes and single-molecule magnets (SMMs) are promising prototypes that can reach magnetic bistability within the molecular scale required for data storage. Despite the extensive library of versatile ...
Kennington, Stuart (Date of defense: 2020-12-21)
This thesis focuses on the search for new methodologies for the direct, stereoselective and catalytic formation of carbon-carbon bonds through the formation of chiral nickel(II) enolate species and the application of such ...
Bonelli Blasco, Joaquin Daniel (Date of defense: 2022-12-14)
[eng] Nanomedicine is one of the cutting-edge fields in most of medical applications, specially, in oncology. The possibility to selectively vehiculize and specifically release a wide range of anticancer compounds gained ...
Presa i Rodríguez, Andreu (Date of defense: 2016-12-16)
The photoactivation of metal complexes with potential anticancer activity is a hot topic of current research, as it may lead to the development of more selective and efficient drugs. Photoactivated chemotherapy (PACT) with ...
Velasco Amigó, Verónica (Date of defense: 2016-10-28)
Desde hace años la ciencia del magnetismo ha centrado uno de sus objetivos más ambiciosos en el estudio y creación de dispositivos funcionales a escala molecular. Un ejemplo es el intento de implementación de la computación ...
Iruela Martin, Guillermo (Date of defense: 2021-09-16)
c-Src tyrosine kinase is associated with poor prognosis in many cancer processes. Although inhibitors of c-Src kinase activity are known, they have not reached success in clinical trials because of lack of selectivity or ...