Browsing Departament de Química Inorgànica i Orgànica by Title

Compostos organometàl·lics amb fosfines P-esterogèniques diaríliques: aplicacions en catàlisi homogènia enantioselectiva

Clavero Puyal, Pau (Date of defense: 2016-07-25)

La Tesi tracta sobre la preparació i l’ús en catàlisi homogènia asimètrica de lligands fosforats quirals amb àtoms de fòsfor estereogènics. En primer lloc es descriu la preparació i caracterització de lligands monofosforats ...

Computational insights into carbohydrate epimerase mechanisms

Esquivias Bautista de Lisbona, Oriol (Date of defense: 2023-11-17)

[eng] Carbohydrates, as the most abundant biomolecules, play a myriad of roles and functions in biological systems. Unlike the building blocks of proteins, amino acids, whose chemical structure can vary significantly, ...

Conformational and mechanistic analyses of α- and β-glycosidase substrates by ab initio QM/MM methods

Alonso Gil, Santiago (Date of defense: 2017-07-12)

Carbohydrates are one of the most important biochemical molecules due to their role as energetic resource for non-photosynthetic organisms, cell-cell recognition and adhesion, protection of cell membranes of bacteria and ...

Coordination, organometallic and supramolecular chemistry approaches to the design of metal-based cytotoxic agents

Faustino Brissos, Rosa Maria (Date of defense: 2018-04-13)

The discovery of cisplatin and its successful use as chemotherapeutic agent have encouraged the development of metal-based anticancer molecules. The present doctoral research project includes three different chemistry ...

COUPY coumarins as privileged scaffolds for the development of novel targeted fluorophores and metalbased PDT anticancer agents

Rovira Vidal, Anna (Date of defense: 2023-03-03)

[eng] In this Thesis, we have explored the applications in cancer diagnosis and therapy of COUPY fluorophores, a new family of compounds based on the coumarin structure and operating in the far-red to near infrared region ...

Cyclometallated platinum compounds: optical and biological applications

Lázaro Palacios, Ariadna (Date of defense: 2023-05-05)

[eng] This Doctoral Thesis is focused on the synthesis of cyclometallated platinum compounds with different structural modifications rationally designed specifically for biological or optical applications. Specifically, ...

Desenvolupament d'una síntesi industrialitzable d'un fàrmac

López Barallobre, Blanca (Date of defense: 2016-09-21)

Posar al mercat un nou fàrmac és un procés molt llarg i costós i que comporta un risc econòmic important per una empresa farmacèutica. En canvi, el desenvolupament d'un procediment millorat per a la producció d'un fàrmac ...

Desenvolupament de processos per a la síntesi de pèptids d’interès terapèutic a escala industrial

Duran Corbera, Macarena (Date of defense: 2021-09-30)

Investigacions recents en el camp de la biomedicina han demostrat que les interaccions entre pèptids i macromolècules com ara les proteïnes, modulen i regulen processos biològics importants com la memòria, la resposta a ...

Design and preparation of functional coordination compounds based on poly-β-diketone and polypyrazolyl ligands

Borilović, Ivana (Date of defense: 2018-11-23)

Combining the judiciously designed bis−β-diketone and polypyrazolyl scaffolds with the crystal field effects on the 3d metal ions, this manuscript exposes different methods of selective preparation of new heterometallic ...

Design and synthesis of photoswitchable coordination complexes

Salinas Uber, Jorge (Date of defense: 2016-07-29)

One of the main objectives of this thesis was the synthesis of new chelating ligands containing a photochromic unit able to change its conformation upon light irradiation. This isomerization should serve to modify the ...

Design and synthesis of selective MMP-9 inhibitors for the treatment of epilepsy

Bertran Junqué, Alexandra (Date of defense: 2018-10-25)

Matrix metalloproteinases (MMPs) are a family of zinc-containing endopeptidases involved in the degradation of the extracellular matrix. They make a major contribution to the progression of a vast number of diseases, ...

Design of Catalytic Systems based on Halogen Bonding Interactions: Synthesis and Application in Catalytic Reactions

Martínez Bascuñana, Alba (Date of defense: 2023-09-01)

[eng] The use of supramolecular interactions in catalysis has been widely studied and exploited for the straightforward preparation of the backbones of an array of structurally diverse stereoselective catalysts. In addition ...

Design of novel compositionally controlled hybrid and ternary nanostructures

Dalmases Solé, Mariona (Date of defense: 2019-02-08)

The size/shape dependent and unique physical and chemical properties presented by nanostructured materials have attracted great attention in several fields such as energy harvesting, optoelectronics and biomedicine, among ...

Design, synthesis and evaluation of the biological properties of colistin analogues

Solé Solé, Judith (Date of defense: 2022-06-03)

Following the laws of evolution, bacteria are capable of slowly but inexorably acquiring resistance to antibiotic compounds that we have been using for decades. Therefore, bacteria that seemed harmless to most people (such ...

Design, synthesis and study of coordination complexes with spin crossover or single-molecule magnet properties

Diego Creixenti, Rosa (Date of defense: 2022-01-21)

Spin crossover (SCO) complexes and single-molecule magnets (SMMs) are promising prototypes that can reach magnetic bistability within the molecular scale required for data storage. Despite the extensive library of versatile ...

The development of new, direct and asymmetric Ni(II) catalysed carbon-carbon bond forming reactions and their application to total synthesis

Kennington, Stuart (Date of defense: 2020-12-21)

This thesis focuses on the search for new methodologies for the direct, stereoselective and catalytic formation of carbon-carbon bonds through the formation of chiral nickel(II) enolate species and the application of such ...

Development of novel nanomedicines based on polyurethane-polyurea hybrid nanocapsules for cancer theragnosis

Bonelli Blasco, Joaquin Daniel (Date of defense: 2022-12-14)

[eng] Nanomedicine is one of the cutting-edge fields in most of medical applications, specially, in oncology. The possibility to selectively vehiculize and specifically release a wide range of anticancer compounds gained ...

Diarylethene-based Pt(II) molecular switches: a novel approch to photoactivated chemotherapy

Presa i Rodríguez, Andreu (Date of defense: 2016-12-16)

The photoactivation of metal complexes with potential anticancer activity is a hot topic of current research, as it may lead to the development of more selective and efficient drugs. Photoactivated chemotherapy (PACT) with ...

Diseño de ligandos β-dicetona y sus agregados metálicos funcionales: estudio cristalográfico y magnético

Velasco Amigó, Verónica (Date of defense: 2016-10-28)

Desde hace años la ciencia del magnetismo ha centrado uno de sus objetivos más ambiciosos en el estudio y creación de dispositivos funcionales a escala molecular. Un ejemplo es el intento de implementación de la computación ...

Drug discovery with a FRET Biosensor of scaffolding interactions in the N-terminal region of c-Src = Descubrimiento de fármacos mediante un biosensor basado en FRET sensible a las interacciones en la región N-terminal de c-Src

Iruela Martin, Guillermo (Date of defense: 2021-09-16)

c-Src tyrosine kinase is associated with poor prognosis in many cancer processes. Although inhibitors of c-Src kinase activity are known, they have not reached success in clinical trials because of lack of selectivity or ...