Departament de Química Inorgànica i Orgànica: Recent submissions
Now showing items 41-60 of 93
Síntesi assistida per microones de molècules imant i nanoestructuració en sistemes híbrids amb nanopartícules d’òxid de ferro
L’obtenció de dispositius per aplicacions tecnològiques a la nanoescala implica l’ús de molècules que permeten la miniaturització d’aquests, aconseguint així més eficiència en menys espai. Les molècules que s’utilitzen ...
Aproximació a la síntesi de la iriomoteolida-2a i avaluació in silico de la interacció amb actina. Intents d’un nou mètode de RCM amb formació de dobles enllaços trisubstituïts
La present Tesi Doctoral descriu tots els esforços dedicats a la síntesi total de la iriomoteolida- 2a, un nou macròlid aïllat per Tsuda i col·laboradors a l’illa d’Iriomote (Japó) l’any 2015. Exhibeix una moderada ...
Bioconjugació de poliols i tiols amb agents antivírics
El VIH-1 segueix essent un dels problemes més greus de la sanitat pública mundial, especialment als països del tercer món. La fase més avançada de la infecció pel VIH és la SIDA (síndrome d’immunodeficiència adquirida). La ...
Semiconductores orgánicos derivados del carbazol y su aplicación en dispositivos electrónicos
En los últimos años se han llevado a cabo intensas investigaciones dentro del campo de los materiales orgánicos semiconductores, principalmente enfocados a su aplicación en dispositivos electrónicos y optoelectrónicos como ...
Preparation of CBs immobilized on different types of magnetic nanoparticles for application in selective complexation and catalysis
Cucurbiturils are known to present potential applications in molecular recognition, self- assembly, and nanotechnology. The discovery of ultra-high affinity CB–guest complexes with binding constant values similar than those ...
Anisotropía Magnética en Imanes Moleculares y Qubits con Complejos Metálicos de Espín ½
Esta tesis presenta una serie de estudios computacionales basados en métodos de estructura electrónica en los que se analizan la anisotropía magnética y las propiedades derivadas de esta en complejos magnéticos candidatos ...
Simple and double conjugates of peptides and oligonucleotides
2,2-Disubstituted cyclopent-4-ene-1,3-diones (CPDs), which have been as non-hydrolysable maleimide analogs, have been found to possess an unexpected reactivity with N-terminal cysteines. Whilst maleimides react in an ...
Understanding the transport mechanism of BBB peptide shuttles: THRre and MiniAp-4 as case studies
The research work presented in this thesis aims to understand the transport mechanism of two described BBB-shuttles, THRre and MiniAp-4. To achieve these objectives, different techniques have been used as solid phase peptide ...
Reacciones directas y estereoselectivas de N-aciltioimidas quirales catalizadas por complejos de níquel(II). Síntesis de derivados de la anti ß-hidroxitirosina
En la presente tesis doctoral se ha desarrollado y expandido la metodología estereoselectiva, catalítica y de tipo directa en la cual enolatos de níquel(II) de N-acil tiazolidintionas quirales reaccionan con un amplio grupo ...
Pushing peptides further: Novel methodologies for the synthesis of backbone-modified peptides
Peptides and proteins are essential substances for living organisms, as they can be found in every cell and tissue and are involved in many biological and physiological processes. Given their intrinsic properties and their ...
Oligopeptides as highly versatile agents against copper-mediated oxidative stress and amyloid-β aggregation
Alzheimer’s disease (AD), for which no cure is known yet, is currently the most prevalent cause of dementia for the elderly population. The aberrant aggregation of β-amyloid peptide (Aβ) is believed to trigger the events ...
P-Stereogenic ligands with the tert-butylmethylphosphine fragment. Coordination chemistry and catalysis of their organometallic complexes
The Thesis deals with the preparation, coordination chemistry and use in asymmetric homogeneous catalysis of several optically pure P-stereogenic ligands containing a tert-butylmethylphosphino fragment. In the first part ...
Design of novel compositionally controlled hybrid and ternary nanostructures
The size/shape dependent and unique physical and chemical properties presented by nanostructured materials have attracted great attention in several fields such as energy harvesting, optoelectronics and biomedicine, among ...
Synthesis of TGF-Beta inhibitors and compounds for spatiotemporal drug release
During this doctoral thesis, we have synthesised hundreds of grams of the TGF-β inhibitor LY2157299 (Galunisertib). This product was used by the group of Eduard Batlle in their investigations into the roles that TGF-β plays ...
Design and preparation of functional coordination compounds based on poly-β-diketone and polypyrazolyl ligands
Combining the judiciously designed bis−β-diketone and polypyrazolyl scaffolds with the crystal field effects on the 3d metal ions, this manuscript exposes different methods of selective preparation of new heterometallic ...
Titanium(IV) enolate chemistry applied to the stereoselective construction of C–C and C–O bonds. New ionic and radical processes
In the present Thesis we continued a previous study of the nucleophilic character of titanium(IV) enolates. Particularly,we focused our attention on the analysis of substrate-controlled Michael additions to enones and other ...
P-Stereogenic Intermediates and MaxPHOX ligands. Iridium Catalyzed Asymmetric Hydrogenations
Asymmetric hydrogenation of double bonds by means of organometallic catalysis is a powerful tool for organic synthesis; it is an efficient and simple method to produce valued chiral compounds. Among the many different ...
Novel chemical tools for Cancer therapy and imaging: from targeted photoactivatable Pt(IV) complexes to coumarin-based fluorophores and caging groups
In the present Thesis, it has been carried out the development of new chemical tools for the diagnosis and treatment of cancer through the use of light as an external factor. On the one hand, light can be used to control, ...
Somatostatin analogues as drug delivery systems for receptor-targeted cancer therapy
Somatostatin (SST or SRIF14) is a peptidic hormone secreted throughout the central nervous system and in the gastrointestinal tract which has anti-secretory, anti-proliferative and anti-angiogenic effects. Although its ...
Design and synthesis of selective MMP-9 inhibitors for the treatment of epilepsy
Matrix metalloproteinases (MMPs) are a family of zinc-containing endopeptidases involved in the degradation of the extracellular matrix. They make a major contribution to the progression of a vast number of diseases, ...
