Open-chain building blocks from chiral lactams. Enantioselective synthesis of macrocyclic nitrogen-containing natural products 

    Guignard, Guillaume Michel Pablo (Date of defense: 2016-06-23)

    1. (R)-Phenylglycinol-derived oxazolopiperidone lactams can be converted to enantiopure open-chain amino ester scaffolds by alkaline hydrolysis of the N-Boc 2-piperidones resulting from the reductive cleavage of the ...

    New Palladium-Catalysed Intramolecular Coupling Reactions: Nucleophilic Addition toAldehydes and C-H Carbene Insertion 

    Mariani, Francesco (Date of defense: 2016-07-05)

    Although sygma-aryl and sygma-vinylpalladium(II) complexes are commonly used as electrophiles in C—C bond forming reactions, recent research has demonstrated that the same palladium intermediates can also react with ...

    Development of a divergent strategy towards the synthesis of lycopodium alkaloids 

    Saborit Villarroya, Gisela (Date of defense: 2016-07-19)

    En la present tesi doctoral s’ha desenvolupat una estratègia per obtenir els esquelets dels quatre alcaloides licopodi representatius a partir d’un mateix intermedi sintètic comú 1, de manera semblant al procés que té lloc ...

    Enantio- and Diastereoselective Cyclocondensation Reactions. Stereocontrolled Access to Azabicycles and Application to Natural Product Synthesis 

    Ghirardi, Elena (Date of defense: 2016-07-28)

    The first objective of this Thesis was the study of the preparation of octhydro-1H-cyclopenta[b]pyridines and octahydro-1H-indoles, through the synthesis of (R)-phenylglycinol derived tricyclic lactams. Following the ...

    Total Synthesis of Phlegmarine Alkaloids 

    Bosch, Caroline (Date of defense: 2016-10-21)

    This doctoral thesis consists in two main parts. The first part focus in the study of methodology development in order to bring modularity and diversification to compounds studied within the research group. It consists ...

    Design and synthesis of sphingosine-1-phosphate lyase inhibitors and fluorogenic probes for the development of HTS assays 

    Sanllehí Figuerola, Pol (Date of defense: 2016-11-02)

    Sphingolipids (SLs) are essential structural and signaling molecules of eukaryotic cells. An important group of SLs metabolites are those showing a phosphate group at the C1‒ OH. Among them, sphingosine‒1‒phosphate (S1P) ...

    Novel approaches toward anti-Alzheimer and antiprotozoal drug candidates 

    Sola Lao, Irene (Date of defense: 2016-11-15)

    This PhD Thesis pursues the development of novel anti-Alzheimer and antiprotozoal drug candidates upon exploitation of three different novel approaches: Multitarget therapies, Drug repurposing, and Validation of a novel ...

    Nuevas aproximaciones a compuestos policíclicos complejos y transformaciones de los mismos 

    Otermin Esteras, Ane (Date of defense: 2016-11-23)

    En esta Tesis doctoral, se ha puesto a punto una ruta sintética para acceder de manera rápida y eficaz, a compuestos policíclicos tipo “cinturón” que contienen dos dobles enlaces C=C casi paralelos y próximos en el espacio. ...

    Participación de la modulación epigenética en modelos murinos de envejecimiento y enfermedad de Alzheimer 

    Griñán Ferré, Christian (Date of defense: 2016-12-12)

    Existe una correlación positiva entre el incremento de la esperanza de vida y el aumento de las enfermedades crónicas. Se ha establecido que el envejecimiento es el principal factor de riesgo en la aparición de trastornos ...

    Toward the Synthesis of Daphniphyllum Alkaloids using Radical Chemistry 

    Coussanes, Gilhem (Date of defense: 2016-12-16)

    The manuscript of this Doctoral Thesis has been divided into five main parts: a general introduction into the calyciphylline A-type alkaloids followed by three research chapters and conclude by a review about the radical ...

    Chloroacetamides as Valuable Synthetic Tools to Access Nitrogen-Containing Heterocycles Using Both Radical and Non-Radical Processes 

    Montiel Achong, Juan Andrés (Date of defense: 2016-12-20)

    Durante este trabajo de tesis doctoral se ha demostrado que las cloroacetamidas son intermedios de gran utilidad para la síntesis de heterociclos nitrogenados a través de procesos radicalarios o no radicalarios. En este ...

    New polycyclic small molecules as ion channel modulators 

    Barniol Xicota, Marta (Date of defense: 2017-01-13)

    L’objectiu de la present tesi doctoral consisteix en desenvolupar molècules policícliques de baix pes molecular que tinguin com a diana tres canals iònics específics: la viroporina A/M2 del virus de la grip, el receptor ...

    Characterization of epigenetic and transcriptional changes in aging and Alzheimer’s disease 

    Cosín Tomàs, Marta (Date of defense: 2017-02-28)

    Epigenetic changes are currently recognized as part of the aging process and have been implicated in many age-related chronic diseases such as Alzheimer’s disease (AD). The term epigenetics includes a variety of processes ...

    Synthesis of 2-Vinyl sphingolipids as S1PL inhibitors 

    Calderón i Almendro, Raquel (Date of defense: 2017-03-14)

    Sphingolipids (SLs) are components of eukaryotic cell membranes that in the last 30 years have shown not only a structural role but also be involved in signaling processes and cellular responses. Therefore, the development ...

    Efectes metabòlics, vasculars i cognitius del consum de sucres simples en rates femella 

    Sangüesa Puigventós, Gemma (Date of defense: 2017-04-18)

    En les últimes dècades, l’increment del consum de sucres, especialment de fructosa, s’ha associat al desenvolupament de la obesitat i d’alteracions metabòliques com ara diabetis, hipertensió i malalties cardiovasculars. ...

    Novel multi-target directed ligands as drug candidates against Alzheimer’s disease 

    Pérez Areales, Francisco Javier (Date of defense: 2017-07-14)

    Alzheimer’s disease (AD) is the main neurodegenerative disorder and one of the most important health-care problems worldwide, because of its high prevalence and personal and economic impact. To aggravate this situation, ...

    Novel ᴫ-Functional Components of Micro- and Nanoparticles for Nanomedicine 

    Alea Reyes, María Elisa (Date of defense: 2017-07-17)

    The present thesis is included in the area of Nanomedicine and supramolecular chemistry, focused on the design and preparation of different nano and microtools for delivery, therapy and sensing. Initially, the synthesis ...

    Development of New Multicomponent Processes based on Unexplored Chemistry of Isocyanides: Access to Heterocyclic Scaffolds and Applications 

    Ghashghaei, Ouldouz (Date of defense: 2017-09-26)

    1. It was observed that the interaction of imines and isocyanides in the presence of a Lewis acid can lead to a variety of scaffolds including α-aminoamides, α-aminoamidines, indoles and diiminoazetidines. The reaction ...

    Common scaffolds for the enantioselective synthesis of marine, plant, and amphibian cis-decahydroquinoline alkaloids 

    Pinto, Alexandre (Date of defense: 2017-09-28)

    Chiral amino alcohol derived lactams are a valuable scaffold for the enantioselective synthesis of alkaloids. In the present thesis the potential of this methodology was expanded and to demonstrate the synthetic utility ...

    Mecanismos implicados en la neurodegeneración inducida por dieta grasa en modelos de senescencia 

    Palomera Ávalos, Verónica (Date of defense: 2018-01-26)

    La población mundial está envejeciendo, la mayoría de países del mundo están experimentando un aumento en el número y la proporción de personas mayores. Los últimos datos publicados de la ONU en 2017 informan que se espera ...