Departament de Farmacologia, Toxicologia i Química Terapèutica: Recent submissions
Now showing items 41-50 of 50
Toward the Synthesis of Daphniphyllum Alkaloids using Radical Chemistry
The manuscript of this Doctoral Thesis has been divided into five main parts: a general introduction into the calyciphylline A-type alkaloids followed by three research chapters and conclude by a review about the radical ...
New polycyclic small molecules as ion channel modulators
L’objectiu de la present tesi doctoral consisteix en desenvolupar molècules policícliques de baix pes molecular que tinguin com a diana tres canals iònics específics: la viroporina A/M2 del virus de la grip, el receptor ...
Novel approaches toward anti-Alzheimer and antiprotozoal drug candidates
This PhD Thesis pursues the development of novel anti-Alzheimer and antiprotozoal drug candidates upon exploitation of three different novel approaches: Multitarget therapies, Drug repurposing, and Validation of a novel ...
Nuevas aproximaciones a compuestos policíclicos complejos y transformaciones de los mismos
En esta Tesis doctoral, se ha puesto a punto una ruta sintética para acceder de manera rápida y eficaz, a compuestos policíclicos tipo “cinturón” que contienen dos dobles enlaces C=C casi paralelos y próximos en el espacio. ...
Design and synthesis of sphingosine-1-phosphate lyase inhibitors and fluorogenic probes for the development of HTS assays
Sphingolipids (SLs) are essential structural and signaling molecules of eukaryotic cells. An important group of SLs metabolites are those showing a phosphate group at the C1‒ OH. Among them, sphingosine‒1‒phosphate (S1P) ...
Total Synthesis of Phlegmarine Alkaloids
This doctoral thesis consists in two main parts. The first part focus in the study of methodology development in order to bring modularity and diversification to compounds studied within the research group. It consists ...
Development of a divergent strategy towards the synthesis of lycopodium alkaloids
En la present tesi doctoral s’ha desenvolupat una estratègia per obtenir els esquelets dels quatre alcaloides licopodi representatius a partir d’un mateix intermedi sintètic comú 1, de manera semblant al procés que té lloc ...
New Palladium-Catalysed Intramolecular Coupling Reactions: Nucleophilic Addition toAldehydes and C-H Carbene Insertion
Although sygma-aryl and sygma-vinylpalladium(II) complexes are commonly used as electrophiles in C—C bond forming reactions, recent research has demonstrated that the same palladium intermediates can also react with ...
Enantio- and Diastereoselective Cyclocondensation Reactions. Stereocontrolled Access to Azabicycles and Application to Natural Product Synthesis
The first objective of this Thesis was the study of the preparation of octhydro-1H-cyclopenta[b]pyridines and octahydro-1H-indoles, through the synthesis of (R)-phenylglycinol derived tricyclic lactams. Following the ...
Open-chain building blocks from chiral lactams. Enantioselective synthesis of macrocyclic nitrogen-containing natural products
1. (R)-Phenylglycinol-derived oxazolopiperidone lactams can be converted to enantiopure open-chain amino ester scaffolds by alkaline hydrolysis of the N-Boc 2-piperidones resulting from the reductive cleavage of the ...
