Browsing Departament de Biomedicina by Subject "616"

Now showing items 1-8 of 8

Aberrant TIMP-1 regulation in tumor-associated fibroblasts by the TGF-β1/SMAD3 pathway in lung cancer: implications in tumor progression and resistance to antifibrotic therapies

Duch Gili, Paula (Date of defense: 2022-03-14)

Increased expression of TIMP-1 is associated with poor prognosis in virtually all cancer types, including lung cancer. However, how TIMP-1 is regulated in lung cancer and how it drives tumor progression is poorly defined. ...

Cholesterol and StARD1: a common nexus in Alcoholic Liver Injury and Niemann-Pick Type C disease-associated mitochondrial stress

Solsona i Vilarrasa, Estel (Date of defense: 2021-03-22)

[eng] Cholesterol accumulation in mitochondrial membranes is a common feature of various chronic diseases, such as cardiovascular disease, cancer, and Alzheimer's as well as liver diseases. Studies prior to this doctoral ...

Effects of human serum albumin on TNFα-induced cell death and mitochondrial dysfunction in the liver cells

Duran Güell, Marta (Date of defense: 2023-04-12)

[eng] Albumin exerts pleiotropic actions beyond its oncotic power, which include binding, transport and detoxification of endogenous and exogenous molecules, antioxidant activity and the modulation of immune and inflammatory ...

El paper de p27 a la regulació de la via de Notch

Durán Rodríguez, Rodrigo (Date of defense: 2022-01-28)

Partint dels resultats previs obtinguts per aquest grup d’investigació, es planteja la següent hipòtesi de treball: “La proteïna p27 és un regulador de la via de Notch. Aquesta regulació es realitzaria, principalment, ...

Estimació del risc de neoplàsia colorectal avançada a partir de la quantificació de l’hemoglobina fecal en el cribratge del càncer de còlon i recte

Augé Fradera, Josep Maria (Date of defense: 2017-05-26)

INTRODUCCIÓ: A nivell mundial el càncer de còlon i recte (CCR) és el segon i el tercer en freqüència en homes i en dones, respectivament. La seva història natural és coneguda, se sap que habitualment es desenvolupa a ...

Machine Learning for predicting Immunotherapy response from routine Medical Imaging

Ligero Hernández, Marta (Date of defense: 2024-03-15)

[eng] HYPOTHESIS: Precision oncology has revolutionized the landscape of cancer treatment. Emerging therapeu- tic approaches, such as immunotherapy or anti-angiogenic agents, have exhibited remarkable outcomes in solid ...

Myeloid p38 MAPK signaling in intestinal homeostasis, inflammation and tumorigenesis = Señalización por la MAPK p38 de células mieloides en la homeostasis, inflamación y tumorogénesis intestinal

Youssif, Catrin (Date of defense: 2017-10-27)

Chronic inflammation is a hallmark of colon cancer, and patients with inflammatory bowel disease are prone to developing colon tumors. In recent years, many efforts have been devoted to characterize the interplay between ...

New insights into ionotropic glutamate receptors in physiological and pathological conditions

Miguez Cabello, Federico (Date of defense: 2021-02-09)

[eng] Speaking metaphorically, the human nervous system is a complex ensemble of millions of parts operating together one with another. For this reason, each part is fundamental for the correct function of the whole system. ...