Browsing Departament de Ciències Fisiològiques by Subject "577"

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Genetic and biochemical approaches to decipher the molecular basis of the pathology in LCA12 and RP10 retinal dystrophies

Plana-Bonamaisó, Anna Maria (Date of defense: 2020-05-15)

The main aim of this work was to characterize the molecular mechanisms that underlie the physiopathology of LCA12 and RP10, that are inherited retinal dystrophies caused by alterations in guanine nucleotide metabolism. First, ...

Physiological relevance of the E3 ubiquitin ligase HERC1

Martínez Martínez, Arturo (Date of defense: 2022-12-02)

[spa] HERC1 es una E3 ubicuitina ligasa de la familia HECT. Mutaciones en el gen de HERC1 han sido relacionadas con diferentes tipos de cánceres y enfermedades neurodegenerativas. En esta tesis, demostramos que HERC1 ...

White adipose tissue characterization and lipid profiling in obesity

Dahdah, Norma (Date of defense: 2022-07-27)

[eng] Obesity has become exceedingly pervasive, a resultant of amplified food availability and reshaped human behavior stimulated by urbanization. It poses as a major challenge for human metabolic physiology testing ...