Greguske, Erin A. (Date of defense: 2019-07-11)
Progressive ototoxicity of the inner ear is prevalent in patients administered aminoglycoside antibiotics with little understanding of how this damage occurs and to what extent it can be recovered. ...
Hyroššová, Petra (Date of defense: 2017-05-26)
Phosphoenolpyruvate carboxykinase (PEPCK) is an enzyme that catalyses decarboxylation of oxaloacetate to phosphoenolpyruvate and it is part of gluconeogenic/glyceroneogenic pathway. There are two known ...
Sánchez de Diego, Cristina (Date of defense: 2021-01-28)
[spa] El hueso es un órgano con múltiples funciones. No sólo actúa como elemento de soporte, protección y locomoción, sino que también resulta indispensable en el mantenimiento del equilibrio mineral ...
Aragó Belenguer, Marc (Date of defense: 2022-06-30)
[spa] La reprogramación metabólica es uno de los procesos que caracterizan el cancer. Estos cambios en el metabolismo de las células tumorales no solo permiten a las células obtener los metabolitos ...
Dahdah, Norma (Date of defense: 2022-07-27)
[eng] Obesity has become exceedingly pervasive, a resultant of amplified food availability and reshaped human behavior stimulated by urbanization. It poses as a major challenge for human metabolic ...
Martínez Martínez, Arturo (Date of defense: 2022-12-02)
[spa] HERC1 es una E3 ubicuitina ligasa de la familia HECT. Mutaciones en el gen de HERC1 han sido relacionadas con diferentes tipos de cánceres y enfermedades neurodegenerativas. En esta tesis, ...
López Begines, Santiago (Date of defense: 2016-11-18)
In photoreceptor cells of the retina, light triggers a protein G-mediated enzymatic cascade that leads to hydrolysis of cGMP. The drop in cGMP levels causes the closure of cGMP-channel at the plasma ...
Simon Molas, Helga (Date of defense: 2019-07-05)
The TP53-Induced Glycolysis and Apoptosis Regulator (TIGAR) gene was described in 2006 by Dr. Karen Vousden's group in response to the induction of the tumour suppressor gene p53. Since then, numerous ...
Stanzani, Elisabetta (Date of defense: 2016-09-16)
Glioblastoma (GBM) is the most frequent and malignant primary brain tumor. The current standard of care for adult patient with diagnosed GBM is surgery followed by radiotherapy (RT) plus concomitant and ...
Aquino Martínez, Rubén Francisco (Date of defense: 2016-09-22)
At least two specific features differentiate bone from other tissues, a blend of organic and mineral components, and a cellular organization with a hierarchical commitment degree. During bone remodeling ...