dc.contributor
Universitat Jaume I. Escola de Doctorat
dc.contributor.author
Porru, Simona
dc.date.accessioned
2020-02-24T07:54:35Z
dc.date.available
2020-02-24T07:54:35Z
dc.date.issued
2020-02-04
dc.identifier.uri
http://hdl.handle.net/10803/668703
dc.description.abstract
The abundant expression of Extracellular signal-Regulated Kinase (ERK) in brain areas of addiction emphasizes the relevance of this kinase in modulating behavioral functions mediated by these circuits. Another biochemical factor involved in this process is Dopamine and cAMP-regulated phosphoprotein Mr 32,000 kDa (DARPP-32), which regulates the activity and the phosphorylation state of ERK pathway. Thus, the general aim of the present doctoral
thesis was to study the role of ERK in terms of protein kinase expression induced by
ethanol, caffeine and their association, and its relationship with some behavioral
responses in validated animal models of drug addiction such as the response to stimuli
associated to their intrinsic properties and conditioned to the environment (place
conditioning), or the psychomotor activation mediated by these substances.
dc.description.abstract
La abundante expresión de Extracellular signal-Regulated Kinase (ERK) en áreas cerebrales de
adicción enfatiza la relevancia de esta quinasa en la modulación de las funciones conductuales
mediadas por estos circuitos. Otro factor involucrado en este proceso es Dopamine and
cAMP-regulated phosphoprotein Mr32,000kDa (DARPP-32), que regula la actividad y el estado
de fosforilación de ERK.
dc.format.mimetype
application/pdf
dc.publisher
Universitat Jaume I
dc.rights.license
L'accés als continguts d'aquesta tesi queda condicionat a l'acceptació de les condicions d'ús establertes per la següent llicència Creative Commons: http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.uri
http://creativecommons.org/licenses/by-nc-nd/4.0
*
dc.source
TDX (Tesis Doctorals en Xarxa)
dc.subject
Condicionamiento de lugar
dc.subject
Extracellular signal-Regulated
dc.subject
Nucleus accumbens
dc.subject.other
Salut i serveis socials
dc.title
Behavioral and neurochemical assessment of the role of ERK pathway in the psychopharmacological effects of ethanol, caffeine and of their interaction
dc.type
info:eu-repo/semantics/doctoralThesis
dc.type
info:eu-repo/semantics/publishedVersion
dc.contributor.director
Correa Sanz, Mercè
dc.contributor.director
Acquas, Elio
dc.rights.accessLevel
info:eu-repo/semantics/openAccess
dc.identifier.doi
http://dx.doi.org/10.6035/14109.2020.773444
dc.description.degree
Programa de Doctorat en Psicologia
cat
