Design, characterization and optimization of a novel liposomal based food supplement against chronic fatigue syndrome

dc.contributor
Universitat de Barcelona. Departament de Farmàcia i Tecnologia farmacèutica i Físicoquímica
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Ruiz García, Marta
dc.date.accessioned
2021-04-16T15:40:07Z
dc.date.available
2021-10-20T02:00:18Z
dc.date.issued
2020-10-20
dc.identifier.uri
http://hdl.handle.net/10803/671428
dc.description.abstract
In today’s society, people’s interest against health care is growing every day. On a health- concerned population, food supplements and nutraceuticals are products with an increasing interest among the global community. This thesis arises as an industrial doctorate project, with the purpose of strengthen the bioavailability and effectivity of the active substances in Reconnect®, a current product commercialized by Vitae Health Innovation, S.L. Coencapsulation of different actives has been widely studied and reported on the last decades, and concretely liposomes have already been used for the encapsulation of the isolated antioxidant actives phosphatidylserine (PS), coenzyme Q10 (CoQ10), reduced nicotinamide adenine dinucleotide (NADH) and vitamin C, but not as a combinatory oral therapy. Coadministration of these actives on a combinatory therapy within the liposomal encapsulation technology may provide a wide and complete supplementation with promising results on chronic fatigue syndrome (CFS) patients or people suffering from general fatigue, among others. Therefore, the design and development of a novel liposomal-based food supplement against chronic fatigue syndrome is of great industrial interest. This thesis is structured on different parts. On first place, the development and validation of a high-performance liquid chromatography (HPLC) method for the simultaneous quantification of CoQ10, PS, and vitamin C was essential for the analysis and characterization of the selected drugs. The second part of the thesis, separated in two chapters, is focused on the design, characterization and optimization of two methods of liposomal production, one based on the thin-film method, being the main axis of the thesis, while the other method based on microfluidic technology was developed on a short research stay within Prof. Jing Fan’s research group of Complex Fluids and Soft Materials at the City College of New York – City University of New York (CCNY – CUNY). Finally, the third part is focused on the scaling up optimization of the most promising results of the liposomal formulation.
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dc.format.extent
293 p.
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application/pdf
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eng
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dc.publisher
Universitat de Barcelona
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ADVERTIMENT. Tots els drets reservats. L'accés als continguts d'aquesta tesi doctoral i la seva utilització ha de respectar els drets de la persona autora. Pot ser utilitzada per a consulta o estudi personal, així com en activitats o materials d'investigació i docència en els termes establerts a l'art. 32 del Text Refós de la Llei de Propietat Intel·lectual (RDL 1/1996). Per altres utilitzacions es requereix l'autorització prèvia i expressa de la persona autora. En qualsevol cas, en la utilització dels seus continguts caldrà indicar de forma clara el nom i cognoms de la persona autora i el títol de la tesi doctoral. No s'autoritza la seva reproducció o altres formes d'explotació efectuades amb finalitats de lucre ni la seva comunicació pública des d'un lloc aliè al servei TDX. Tampoc s'autoritza la presentació del seu contingut en una finestra o marc aliè a TDX (framing). Aquesta reserva de drets afecta tant als continguts de la tesi com als seus resums i índexs.
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TDX (Tesis Doctorals en Xarxa)
dc.subject
Liposomes
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dc.subject
Liposomas
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dc.subject
Suplements nutritius
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Suplementos nutricionales
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Dietary supplements
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Síndrome de fatiga crònica
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dc.subject
Síndrome de fatiga crónica
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dc.subject
Chronic fatigue syndrome
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Desenvolupament de medicaments
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Desarrollo de los medicamentos
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Drug development
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Càpsules (Farmàcia)
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Cápsulas (Farmacia)
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Capsules (Pharmacy)
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dc.subject.other
Ciències de la Salut
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dc.title
Design, characterization and optimization of a novel liposomal based food supplement against chronic fatigue syndrome
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dc.type
info:eu-repo/semantics/doctoralThesis
dc.type
info:eu-repo/semantics/publishedVersion
dc.subject.udc
615
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dc.contributor.director
García Montoya, Encarna
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Maspoch Comamala, Daniel
dc.contributor.tutor
García Montoya, Encarna
dc.embargo.terms
12 mesos
en_US
dc.rights.accessLevel
info:eu-repo/semantics/openAccess


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