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TREX1 and SAMHD1, and Aicardi-Goutières Syndrome

Valverde Estrella, Lorena (Date of defense: 06-02-2015)
Aicardi-Goutières Syndrome (AGS) is a rare encephalopathy which mimics a viral intrauterine infection and is characterized by calcifications of the basal ganglia, cerebral atrophy and IFN-a in the cerebrospinal fluid. AGS ...
Trex1 and Nbs1 as Regulators of the Macrophage Inflammatory Response

Pereira Lopes, Selma Patrícia (Date of defense: 20-02-2014)
Trex1 is an exonuclease that was first identified in mammal cells and due to its role in DNA metabolism was conjectured to have a role in DNA damage repair and cancer. It was unexpected to find that Trex1-/- mice generated ...