Now showing items 53-72 of 107
Bonastre Llort, Ester (Date of defense: 2014-10-30)
El càncer de pulmó afecta 1,6 milions de persones a tot el món, i és la primera causa de mort per càncer. El promig de l’índex de supervivència als 5 anys per tots els càncers està al voltant del 50%, mentre que en el cas ...
Urizarna España, María (Date of defense: 2013-04-26)
En esta tesis se aborda la identificación de factores del pulgón Myzus persicae que podrían participar en el proceso de transmisión del potyvirus del grabado del tabaco, Tobacco etch virus (TEV), y se explora la posibilidad ...
Gómez Miragaya, Jorge (Date of defense: 2018-04-27)
Chemotherapy is a general treatment for most breast tumors and depending on breast cancer subtype combination with targeted anti-hormonal or anti-HER2 therapy is conducted. Taxane-based regimens constitute the most common ...
Bazzocco, Sarah (Date of defense: 2016-01-27)
Colorectal cancer is a disease caused by genetic and epigenetic changes. Inactivation of tumor suppressor genes and activation of oncogenes are key landmarks in tumor progression. However, the list of tumor suppressor genes ...
Romero Sandoval, July Carolina (Date of defense: 2014-12-01)
Atherosclerosis is an inflammatory process characterized by the accumulation of lipids and fibrous elements in large arteries. It is the main underlying pathological process leading to heart attack and stroke. Low-densit ...
Revuelta López, Elena (Date of defense: 2015-12-01)
La dislipemia y la hipoxia tienen un impacto directo en el remodelado vascular y cardiaco. La isquemia cardiaca produce una disfunción generalizada del corazón caracterizada por alteraciones en el metabolismo celular y ...
Fresán Salvo, Ujué (Date of defense: 2016-05-11)
Los insulators son complejos de DNA y proteínas, cuya función no solo consiste en impedir la comunicación enhancer-promotor y/o bloquear la expansión del silenciamiento de la heterocromatina como clásicamente se habían ...
Luscieti, Sara (Date of defense: 2016-11-22)
Iron is an essential micronutrient required for many cellular reactions and a tight regulation of its metabolism is therefore crucial for health. Cellular iron homeostasis relies on the coordination of iron uptake, storage ...
Elias Miró, Maria (Date of defense: 2014-01-24)
La presente tesis se enmarca dentro del estudio de la lesión por isquemia-reperfusión (I/R), y sus efectos sobre la regeneración, en hígados esteatósicos y no esteatósicos. Uno de los principales riesgos en la cirugía ...
Bernadó Morales, Cristina (Date of defense: 2015-04-23)
In response to oncogenic stresses cells activate two different tumor suppressor mechanisms: Oncogene-induced senescence (OIS), a terminal cell proliferation arrest, or oncogene-induced apoptosis (OIA), which leads to cell ...
Álamo Vargas, Patricia (Date of defense: 2012-12-13)
Los modelos de cáncer colorrectal (CCR) generados mediante inyección ortotópica de líneas celulares de CCR humano, cultivadas extensamente in vitro, tienen escasa eficiencia metastásica. Únicamente un porcentaje bajo de ...
Latil de Ros, Derek (Date of defense: 2017-03-07)
Chitosans are a family of linear polysaccharides generally obtained from the chemical deacetylation of chitin derived from crustacean shells that have been reported to have a wide range of bioactivities. However, the ...
Hosseini, Seyed Ali (Date of defense: 2015-05-08)
A complete understanding of complex formation between proteins and ligands, a crucial matter for pharmacology and, more in general, in biomedicine, requires a detailed knowledge of their static and dynamic atomic interactions. ...
Terribas Pérez, Ernest (Date of defense: 2016-01-20)
Malignant peripheral nerve sheath tumour (MPNST) is a soft tissue sarcoma of the peripheral nervous system. Around 50% of MPNSTs develop in the context of the hereditary cancer neurofibromatosis type 1 (NF1), normally ...
Sala Hojman, Ada (Date of defense: 2016-07-15)
LIF is a pleiotropic cytokine that can act as an immunomodulatory factor in different biological processes, such as embryo implantation, organ transplantation tolerance and multiple sclerosis. Here, we have observed that ...
Castel Morales, Pau (Date of defense: 2016-05-09)
The development of high-throughput sequencing technologies has prompted the evaluation of large cohorts of different tumor types. The results from these comprehensive genomic studies have revealed the most commonly mutated ...
Abd El Rahim Metwally, Galal Yahya (Date of defense: 2016-01-13)
Budding yeast (Saccharomyces cerevisiae) cells coordinate cell growth and cell cycle progression essentially during G1, where they must reach a critical cell size to traverse Start and enter the cell cycle. The most upstream ...
Torroba Balmori, Mª Blanca (Date of defense: 2016-11-11)
Development of the spinal cord involves coordination between exposure to localized extracellular signals and controlled activation of intracellular signaling pathways. This way, neuroepithelial cells firstly proliferate ...
Espinosa Ferrer, Sonia (Date of defense: 2015-07-20)
Las enfermedades cardiovasculares son la primera causa de muerte en todo el mundo y representan uno de los desafíos primordiales en la investigación biomédica. La aterosclerosis es causante de la mayoría de las enfermedades ...
Cingolani, Francesca (Date of defense: 2015-07-10)
Sphingolipids (SLs), essential components of cell membranes, are bioactive molecules involved in the regulation of a variety of cellular processes. Ceramide and sphingosine generally mediate anti-proliferative stimuli, ...