Now showing items 93-107 of 107
Gris Ormo, Georgia (Date of defense: 2015-12-04)
The present Doctoral Thesis focuses on the study of the Sigma-1 receptor (σ1R) in the field of pain. This research has been a part of the preclinical σ1R project focusing on drug discovery of σ1R ligands for the treatment ...
Bilbao Girona, Ana (Date of defense: 2019-10-30)
El modelo de negocio de I+D de las compañías farmacéuticas está en crisis desde hace décadas debido a los grandes costes y a la baja productividad. En consecuencia, la identificación de nuevos biomarcadores y el desarrollo ...
Zulaica Gallego, Ester (Date of defense: 1988-01-01)
Se describe la primera síntesis total de los alcaloides indólicos ngouniensina y epingouniensina. La síntesis se basa en la elaboración del sustituyente metileno exocíclico en una etapa posterior a la de construcción del ...
Torres Martínez, Jordi (Date of defense: 1988-01-01)
No cabe duda que ha sido sobretodo la peculiaridad de los biotopos deltaicos lo que ha propiciado el interés por el estudio de los helmintos parásitos de ciertos hospedadores del Delta del Ebro. Cabe advertir, por tanto, ...
Mendes Braz, Mariana (Date of defense: 2014-07-07)
La esteatosis hepática es un factor de riesgo en PH bajo I/R, situación quirúrgica normalmente aplicada en la práctica clínica para reducir el sangrado asociado a las resecciones hepáticas. Teniendo en cuenta tal problemática ...
Garcia Ferrer, Irene (Date of defense: 2015-12-01)
The balance between proteolytic and antiproteolytic activity is crucial in many biological processes such as nutrition, immune defence, virulence and tissue remodelling. Therefore, it is controlled by several mechanisms, ...
Escobedo Pascual, Albert (Date of defense: 2014-11-06)
Nedd4L is a HECT-type E3 ubiquitin ligase (it covalently binds ubiquitin molecules before transferring them to the final substrate). Ubiquitination is a posttranslational modification (PTM) that labels proteins for a variety ...
Pallara, Chiara (Date of defense: 2016-02-04)
Proteins are large biomolecules that play essential functional and structural roles within cells and that typically act through their interaction with other proteins and biomolecules, forming highly specific functional ...
De Mol, Eva (Date of defense: 2014-06-26)
Prostate cancer (PCa) is the second most common cancer in men after lung cancer. Around 1.1 million men worldwide were diagnosed with PCa in 2012. PCa depends essentially on androgen stimulation for growth and cell survival. ...
Riba Moliner, Marta (Date of defense: 2015-12-11)
The focus of this thesis is the use of supramolecular chemistry to functionalize polymers to obtain organic-based materials with a control of their structure and properties. The non-covalent functionalization of polymers ...
Martínez Redondo, Paloma (Date of defense: 2014-06-25)
The chromatin consists of a hierarchical and dynamical structure that is modulated during the different cell cycle stages in order to maintain genome integrity and preserve the genetic information coded in the DNA. The ...
García Cruz, Roseli Marlen (Date of defense: 2013-10-03)
H-Ras es un protooncogen que codifica para dos proteínas por splicing alternativo la p19 y la p21 (1,2). La p21 presenta mayor tamaño y se localiza en la membrana en donde realiza la función de GTPasa que activa múltiples ...
González Burón, Helena (Date of defense: 2014-03-19)
The human Tousled-like kinases 1 and 2 (TLKs) are predicted serine/threonine kinases that show maximal activity in S phase and are transiently inhibited by the DNA damage response (DDR). Both TLKs interact with and ...
Pieretti, Simone (Date of defense: 2016-06-02)
Cholera is an acute diarrheal infection caused by the bacterium Vibrio cholerae. An estimated 2.9 million of cases and about 100000 cholera deaths occur annually all over the world. Upon ingestion of the V. cholerae, the ...
Biayna Rodríguez, Josep (Date of defense: 2016-01-22)
The role of neurofibromin, the product of the Neurofibromatosis Type 1 (NF1) gene, in cell physiology is still not well understood. Considering the different traits associated to NF1 it is clear that neurofibromin participates ...