Now showing items 10-29 of 107
Picchioni, Daria (Date of defense: 2014-10-23)
Our research group focuses on protein translation and more specifically on the mechanism of transfer RNA (tRNA) aminoacylation by a family of essential and universal enzymes called aminoacyl-tRNA synthetases (aaRSs). aaRS ...
Chiesa, Giulio (Date of defense: 2015-12-11)
Spinal bulbar muscular atrophy (SBMA) is a member of the polyglutamine (polyQ) expansion diseases family; the most famous of which is Huntington disease (HD). SBMA is caused by the expansion of the coding region for the ...
Di Guglielmo, Claudia (Date of defense: 2016-02-09)
The heart can be considered the most important organ of our body, as it supplies nutrients to all the cells. When affected from injuries or diseases, the heart function is hampered, as the damaged area is substituted by a ...
Matalonga Borrel, Lesley (Date of defense: 2016-04-15)
Los trastornos lisosomales y la aciduria glutárica tipo I son las enfermedades objeto de este estudio. Dichas enfermedades, pertenecen al numeroso grupo de enfermedades metabólicas hereditarias (EMH) y tienen en común la ...
Martín Abad, Berta (Date of defense: 2013-12-13)
L’epigenètica fa referència als canvis heretables en l'expressió gènica que no són causats per alteracions en la seqüència d'ADN. La metilació de la citosina en el dinucleòtid CpG és una de les modificacions epigenètiques ...
Castaño Miquel, Laura (Date of defense: 2015-01-30)
SUMO, Small Ubiquitin-related MOdifier, es un modificador post-traduccional de la familia de la Ubiquitina, ya que presentan estructuras y mecanismo de conjugación conservados. La unión de SUMO al sustrato puede modificar ...
Püschel, Franziska (Date of defense: 2019-10-31)
Metabolic alterations in cancer cells are primarily caused by oncogenic mutations and cancer cells are more dependent on glucose compared to non-transformed tissue. Targeting the cancer metabolism opens up a new strategy ...
Duran Arqué, Berta (Date of defense: 2020-12-21)
The complex changes that take place in the mature Xenopus oocyte and early embryo are orchestrated in the absence of transcription. Until zygotic transcription starts, after the mid-blastula transition, cells ...
Terré Torras, Berta (Date of defense: 2016-12-13)
The suppression of genome instability by the DNA damage response (DDR) is critical for preventing human diseases characterized by developmental defects, infertility and in some cases, elevated cancer predisposition. After ...
Gállego Culleré, M. (Montserrat) (Date of defense: 1986-01-01)
El desconocimiento generalizado de nuestra base de trabajo, la acarofauna, conlleva que, como paso previo a cualquier otro estudio, deba procederse primariamente a la tarea mucho más ingrata, y a veces poco reconocida, de ...
Abarca Salat, Maria Lourdes (Date of defense: 1986-01-01)
La célula animal puede ser parasitada por un amplio grupo de hongos miceliares y levaduras que desencadenan procesos clínicos característicos: dermatofitosis, micosis profundas, etc. Estos microorganismos han sido objeto ...
Ariño Carmona, Joaquín (Date of defense: 1986-01-01)
Uno de los tipos más interesantes de modificación covalente post-traduccional es la fosforilación de proteínas. Su importancia reside, en que afecta a numerosas vías metabólicas celulares, por lo general a través de los ...
Pascual Domingo, Rosa (Date of defense: 2018-07-03)
The mammary gland develops postnatally and is remodeled, during each estrous cycle and pregnancy, through very dynamic expansions and involutions of its polarized epithelial tree. Moreover, the mammary gland is hierarchically ...
Monterrubio Martínez, Carles (Date of defense: 2016-11-17)
A new combined microdialysis – tumor homogenate method for the determination of compartmental (vascular, extra- and intracellular) SN-38 distribution in patient-derived xenografts (PDX) generated from pediatric solid tumors ...
Molina Martínez, Patricia (Date of defense: 2016-02-09)
La enfermedad de Alzheimer (EA) es la causa más común de demencia neurodegenerativa en los países desarrollados y su prevalencia aumenta con la edad. Los genes cuyas mutaciones son responsables de EA familiar son APP, PSEN1 ...
Plà Solans, Helena (Date of defense: 2014-11-13)
Although survival rates of colorectal cancer (CRC) treated with surgery and conventional chemotherapy are high, metastatic CRC still shows acute mortality rates. Current chemotherapeutic treatment involves high doses of ...
Jiménez García, Brian (Date of defense: 2016-07-21)
Computing has pushed a paradigm shift in many disciplines, including structural biology and chemistry. This change has been mainly driven by the increase in performance of computers, the capacity of dealing with huge amounts ...
Crespo Santiago, Juan (Date of defense: 2016-07-21)
La ingeniería tisular cardíaca ha evolucionado rápidamente en los últimos años, desde los primeros ensayos con diferentes especies animales hasta la producción de la primera generación de tejidos cardíacos humanos que ...
Parra Montes, Claudio (Date of defense: 2015-07-17)
En esta tesis se desarrolla una metodología general para la construcción tándem de manera asimétrica de importantes “building blocks” que se encuentran presentes en la estructuras de muchos productos naturales complejos y ...
Moles Meler, Ernest (Date of defense: 2015-12-09)
Bearing in mind the absence of an effective preventive vaccine against malaria (WHO, 2015) and its severe clinical manifestations that are principally associated with red blood cell (RBC) destruction and parasitized-RBC ...