Browsing Facultat de Farmàcia by Subject "616"

Aged Stem Cells Reprogram Their Daily Rhythmic Functions to Adapt to Tissue-Specific Stress

Peixoto, Francisca de Oliveira (Date of defense: 2017-09-05)

The correct timing of adult stem cell function is essential for tissue homeostasis. Our group was among the first to show that circadian rhythms segregate important stem cell functions along the day. For instance, in mouse ...

Caracterització epigenètica dels elements Alu i el seu paper en la regulació transcripcional

Martín Abad, Berta (Date of defense: 2013-12-13)

L’epigenètica fa referència als canvis heretables en l'expressió gènica que no són causats per alteracions en la seqüència d'ADN. La metilació de la citosina en el dinucleòtid CpG és una de les modificacions epigenètiques ...

CPEB2 in mammary gland homeostasis and breast cancer

Pascual Domingo, Rosa (Date of defense: 2018-07-03)

The mammary gland develops postnatally and is remodeled, during each estrous cycle and pregnancy, through very dynamic expansions and involutions of its polarized epithelial tree. Moreover, the mammary gland is hierarchically ...

Estudio de la vía de señalización de RANK y RANKL en células de mama humanas y generación de ortoxenopacientes de càncer de mama

Palafox Sánchez, Marta (Date of defense: 2014-04-29)

Este proyecto de tesis doctoral se ha centrado en tres objetivos principales: el primero es el estudio de la función de la vía de señalización de RANK-RANKL-OPG en el desarrollo y progresión del cáncer de mama en humanos. ...

Estudios sobre la toxocarosis humana en Barcelona: puesta a punto y ensayo de una técnica diagnóstica

Riera Lizandra, Ma. Cristina (Date of defense: 1991-01-01)

La tesis ha constado de dos partes: 1) Puesta a punto de una técnica EIA para la detección de anticuerpos anti-toxocara y 2) Estudio seroepidemiológico de la población hospitalaria en Barcelona. Se ha utilizado un antígeno ...

Identificació i estudi funcional de nous gens supressors tumorals implicats en càncer de pulmó

Bonastre Llort, Ester (Date of defense: 2014-10-30)

El càncer de pulmó afecta 1,6 milions de persones a tot el món, i és la primera causa de mort per càncer. El promig de l’índex de supervivència als 5 anys per tots els càncers està al voltant del 50%, mentre que en el cas ...

Identification of mechanisms of acquired resistance to taxanes in triple negative breast cancer using patient-derived xenografts: a step closer to clinics

Gómez Miragaya, Jorge (Date of defense: 2018-04-27)

Chemotherapy is a general treatment for most breast tumors and depending on breast cancer subtype combination with targeted anti-hormonal or anti-HER2 therapy is conducted. Taxane-based regimens constitute the most common ...

Identification of novel therapeutic targets and tumor suppressor genes in colon cancer using genome-wide high‐throughput approaches

Bazzocco, Sarah (Date of defense: 2016-01-27)

Colorectal cancer is a disease caused by genetic and epigenetic changes. Inactivation of tumor suppressor genes and activation of oncogenes are key landmarks in tumor progression. However, the list of tumor suppressor genes ...

The Iron Regulatory Protein/Iron Responsive Element (IRP/IRE) system: functional studies of new target mRNAs and pathological implications for novel IRE mutations

Luscieti, Sara (Date of defense: 2016-11-22)

Iron is an essential micronutrient required for many cellular reactions and a tight regulation of its metabolism is therefore crucial for health. Cellular iron homeostasis relies on the coordination of iron uptake, storage ...

Mechanisms behind the oncogene-induced senescence (OIS) – oncogene-induced apoptosis (OIA) decision in cells expressing p95HER2

Bernadó Morales, Cristina (Date of defense: 2015-04-23)

In response to oncogenic stresses cells activate two different tumor suppressor mechanisms: Oncogene-induced senescence (OIS), a terminal cell proliferation arrest, or oncogene-induced apoptosis (OIA), which leads to cell ...

Molecular characterization of neurofibromatosis type 1–associated malignant peripheral nerve sheath tumours and functional identification of genes involved in their pathogenesis

Terribas Pérez, Ernest (Date of defense: 2016-01-20)

Malignant peripheral nerve sheath tumour (MPNST) is a soft tissue sarcoma of the peripheral nervous system. Around 50% of MPNSTs develop in the context of the hereditary cancer neurofibromatosis type 1 (NF1), normally ...

Molecular mechanisms involved in the immunomodulation induced by LIF in cancer

Sala Hojman, Ada (Date of defense: 2016-07-15)

LIF is a pleiotropic cytokine that can act as an immunomodulatory factor in different biological processes, such as embryo implantation, organ transplantation tolerance and multiple sclerosis. Here, we have observed that ...

New targets in tumor angiogenesis to block tumor re-growth and therapeutic resistance

Bassani, Nicklas (Date of defense: 2017-12-15)

Antiangiogenic drugs are used clinically for treatment of different types of cancers and in the case of renal cell carcinoma (RCC) are now standard first-line treatments (Rini, 2009). Nevertheless, these agents mainly serve ...

Patrón de expresión de tres genes como marcador de predicción pronóstica en neuroblastoma. Mecanismos de regulación transcripcional y función de los genes seleccionados”

Mayol Ricart, Gemma (Date of defense: 2013-03-21)

El neuroblastoma (NB) agrupa un espectro muy heterogéneo de tumores que evolucionan de forma radicalmente distinta. La variedad de comportamiento clínico del NB determina el enfoque terapéutico, que puede variar entre un ...