Chiesa, Giulio (Date of defense: 2015-12-11)
Spinal bulbar muscular atrophy (SBMA) is a member of the polyglutamine (polyQ) expansion diseases family; the most famous of which is Huntington disease (HD). SBMA is caused by the expansion of the ...
Escobedo Pascual, Albert (Date of defense: 2014-11-06)
Nedd4L is a HECT-type E3 ubiquitin ligase (it covalently binds ubiquitin molecules before transferring them to the final substrate). Ubiquitination is a posttranslational modification (PTM) that labels ...
Cánovas Bilbao, Begoña (Date of defense: 2017-07-20)
In normal epithelial cells, p38α has a well-established role as a tumor suppressor. However, recent reports have illustrated pro-tumorigenic functions for the p38α pathway by promoting tumor cell survival ...
Román González, Lidia (Date of defense: 2014-01-31)
Within the hematopoietic system, all mature blood cells are generated. Every differentiation step is characterized by the activation of a new, lineage specific, genetic program and the extinction of the ...
Bassani, Nicklas (Date of defense: 2017-12-15)
Antiangiogenic drugs are used clinically for treatment of different types of cancers and in the case of renal cell carcinoma (RCC) are now standard first-line treatments (Rini, 2009). Nevertheless, these ...
Ramírez Cota, Rosa María (Date of defense: 2016-07-05)
The depletion of MZT1 in human cells causes severe mitotic spindle defects. Depleted cells lack centrosomal γ-tubulin and arrest in mitosis with a monopolar spindle configuration. Similarly, double ...
Marques, Joana (Date of defense: 2015-12-14)
Malaria is arguably one of the main medical concerns worldwide because of the numbers of people affected, the severity of the disease and the complexity of the life cycle of its causative agent, the ...
Avó Freixo, Francisco Duque Projecto (Date of defense: 2016-10-20)
The microtubule cytoskeleton plays essential roles during cell division, migration, differentiation, defining cell morphology and organizing intracellular transport. The properties of microtubules, such ...
Moles Meler, Ernest (Date of defense: 2015-12-09)
Bearing in mind the absence of an effective preventive vaccine against malaria (WHO, 2015) and its severe clinical manifestations that are principally associated with red blood cell (RBC) destruction ...
Parra Montes, Claudio (Date of defense: 2015-07-17)
En esta tesis se desarrolla una metodología general para la construcción tándem de manera asimétrica de importantes “building blocks” que se encuentran presentes en la estructuras de muchos productos ...
577 - Material bases of life. Biochemistry. Molecular biology. Biophysics (23)
616 - Pathology. Clinical medicine (12)
615 - Pharmacology. Therapeutics. Toxicology (11)
576 - Cellular and subcellular biology. Cytology (4)
616.1 - Pathology of the circulatory system, blood vessels. Cardiovascular complaints (2)