Facultat de Farmàcia: Recent submissions
Now showing items 41-60 of 107
Equilibri entre la resposta immunitària efectora i reguladora a l'intestí humà sa i inflamat. Relació amb la localització i el tipus de malaltia
El sistema immune gastrointestinal ha de tenir un equilibri entre les respostes tolerogèniques i proinflamatòries per a mantenir la homeòstasi del sistema. Actualment es desconeixen les possibles diferències en la resposta ...
ToxT promoter recognition by ToxR transcription factor, a co-activator within the Vibrio cholerae virulence cascade
Cholera is an acute diarrheal infection caused by the bacterium Vibrio cholerae. An estimated 2.9 million of cases and about 100000 cholera deaths occur annually all over the world. Upon ingestion of the V. cholerae, the ...
Algorithmic and Technical Improvements for Next Generation Drug Design Software Tools
The pharmaceutical industry is actively looking for new ways of boosting the efficiency and effectiveness of their R&D programmes. The extensive use of computational modeling tools in the drug discovery pipeline (DDP) is ...
Insulators: estructura y funciones
Los insulators son complejos de DNA y proteínas, cuya función no solo consiste en impedir la comunicación enhancer-promotor y/o bloquear la expansión del silenciamiento de la heterocromatina como clásicamente se habían ...
Molecular mechanisms of resistance to PI3K inhibitors
The development of high-throughput sequencing technologies has prompted the evaluation of large cohorts of different tumor types. The results from these comprehensive genomic studies have revealed the most commonly mutated ...
Paper de SirT2 en el control epigenètic de la mitosi
La cromatina és una estructura nucleoproteica, dinàmica i jeràrquicament organitzada dins del nucli cel•Iular. La seva estructura, organització i funció està controlada al llarg del cicle cel.lular, per processos epigenètics ...
Structural Modeling and Characterization of Protein Interactions of Biomedical Interest: The Challenge of Molecular Flexibility
Proteins are large biomolecules that play essential functional and structural roles within cells and that typically act through their interaction with other proteins and biomolecules, forming highly specific functional ...
Desarrollo de modelos celulares para estudios terapéuticos en la enfermedad de Alzheimer
La enfermedad de Alzheimer (EA) es la causa más común de demencia neurodegenerativa en los países desarrollados y su prevalencia aumenta con la edad. Los genes cuyas mutaciones son responsables de EA familiar son APP, PSEN1 ...
Biotechnological approaches to cardiac differentiation of human induced pluripotent stem cells
The heart can be considered the most important organ of our body, as it supplies nutrients to all the cells. When affected from injuries or diseases, the heart function is hampered, as the damaged area is substituted by a ...
Estudi de la concentració circulant de vitamina D3 i l’expressió gènica del receptor de vitamina D a teixit adipós en relació a la hipertensió arterial
Diferents estudis epidemiològics evidencien un major risc de desenvolupar hipertensió arterial (HTA) en subjectes amb baixes concentracions circulants de 25 (OH) vitamina D com la deficiència de la vitamina D(3) estan ...
Molecular characterization of neurofibromatosis type 1–associated malignant peripheral nerve sheath tumours and functional identification of genes involved in their pathogenesis
Malignant peripheral nerve sheath tumour (MPNST) is a soft tissue sarcoma of the peripheral nervous system. Around 50% of MPNSTs develop in the context of the hereditary cancer neurofibromatosis type 1 (NF1), normally ...
Supramolecular Strategies to Control the Assembly of Organic-Based Materials
The focus of this thesis is the use of supramolecular chemistry to functionalize polymers to obtain organic-based materials with a control of their structure and properties. The non-covalent functionalization of polymers ...
Using Phosphorodiamidate Morpholino Oligomers (PMOs) to characterize the role of neurofibromin in cell physiology
The role of neurofibromin, the product of the Neurofibromatosis Type 1 (NF1) gene, in cell physiology is still not well understood. Considering the different traits associated to NF1 it is clear that neurofibromin participates ...
Búsqueda de nuevas estrategias y agentes terapéuticos en enfermedades metabólicas hereditarias
Los trastornos lisosomales y la aciduria glutárica tipo I son las enfermedades objeto de este estudio. Dichas enfermedades, pertenecen al numeroso grupo de enfermedades metabólicas hereditarias (EMH) y tienen en común la ...
Post-translational regulation of CPEB4 in cell cycle
Cytoplasmic polyadenylation element binding proteins (CPEBs) are a family of RNA-binding proteins essential for the translational regulation of mRNAs in various biological contexts. CPEBs recognize CPE elements in the 3’ ...
Molecular retention mechanisms of the G1 cyclin/Cdk complex in budding yeast
Budding yeast (Saccharomyces cerevisiae) cells coordinate cell growth and cell cycle progression essentially during G1, where they must reach a critical cell size to traverse Start and enter the cell cycle. The most upstream ...
Selective blockade of the sigma-1 receptor for the treatment of pain of different aetiology: Preclinical studies
The present Doctoral Thesis focuses on the study of the Sigma-1 receptor (σ1R) in the field of pain. This research has been a part of the preclinical σ1R project focusing on drug discovery of σ1R ligands for the treatment ...
Role of the sigma-1 receptor in the sensory-discriminative and affective-motivational components of acute and chronic pain
The present Doctoral Thesis focuses on the study of the sigma-1 receptor (σ1R) in the field of pain. This research has been a part of the preclinical σ1R project focusing on drug discovery of σ1R ligands for the treatment ...
Development of polyvalent erythrocyte- and parasitized erythrocyte-targeted nanovectors as novel site-specific drug delivery approaches for Plasmodium falciparum malaria chemotherapy
Bearing in mind the absence of an effective preventive vaccine against malaria (WHO, 2015) and its severe clinical manifestations that are principally associated with red blood cell (RBC) destruction and parasitized-RBC ...
Antioxidantes y nanoestructuras lipídicas para prevenir el daño solar en tejidos lipoqueratínicos
La formación de radicales libres en el cabello y la piel debido a una excesiva radiación solar, se asocia principalmente a la presencia de los rayos ultravioleta (UV) aunque la radiación infrarroja (IR) también puede ...
