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Modulación metabólica de la oleoil estrona en ratas con sobrepeso
Aunque se ha caracterizado extensamente la eficacia de la administración de la oleoil estrona sobre la pérdida de grasa corporal, todavía no se ha conseguido averiguar su mecanismo de acción. Esta tesis doctoral se ha ...
Modulación Post-Transcripcional de Genes Expresados en Neuronas Serotoninérgicas de Ratón como Nuevas Dianas Terapéuticas en Depresión
La tesis doctoral titulada “Modulación post-transcripcional de genes expresados en neuronas serotoninérgicas de ratón como nuevas dianas terapéuticas en depresión” ha sido realizada en el Instituto de Investigaciones ...
Modulador óptico cuasiestático en la banda del infrarrojo basado en la ritf
Esta tesis doctoral contribuye a la búsqueda de alternativas para la sustitución de la técnica clásica demodulación de la radiación infrarroja, basada en unarueda "chopper". Esta técnica de modulación óptica, seutiliza en ...
Modular evolution of domain repeat proteins. Metal-binding and domain repeats of Metallothioneins in molluscs and chordates
Proteins are composed of domains, a well-defined region within a protein that constitutes a stable, independently folding, compact structural unit, and that usually performs a specific function. During protein evolution, ...
Modular multilevel converters for power system applications
This thesis discusses the operation of the grid-tied modular multilevel converters (MMC) applied on the dc power transmission, particularly on the medium and high-voltage applications. First, it is presented the evolution ...
Modular phosphinooxazolines: synthesis and evaluation in allylic substitutions
La reacción de substitución alílica asimétrica representa un método importante para la generación de enlaces C-C y C-N de forma estereoselectiva (Esquema 1).<br> Las fosfinooxazolinas (Figura 1) fueron descritas originalmente ...
Modular platform for research in microgrids
The present Ph.D. thesis has been developed following an Industrial Ph.D. program and verses on developing a commercial piece of equipment for teknoCEA, a spin-off company from CITCEA-UPC. The thesis is centered on developing ...
Modulated Techniques to Analyse Photoconversion Devices
The urgent need for a sustainable energetic system to mitigate global warming has increased interest in solar energy as a promising solution. Currently, photoconversion technologies generate only a small fraction of the ...
Modulation and control of three-phase PWM multilevel converters
La present tesi doctoral estudia els inversors trifàsics multinivell del tipus denominat de díodes de fixació (diode-clamped converters). Aquests convertidors poden generar tres o més nivells de tensió a cada fase de ...
Modulation of active glucagon-like peptide-1 (glp-1) levels by grape-seed procyanidins
Modulation of active glucagon-like peptide-1 (GLP-1) levels by grape-seed procyanidins Les procianidines del pinyol de raïm (GSPE) poden millorar estats de disrupció de la homeòstasi de la glucosa i es va hipotetitzar que ...
Modulation of adenosine A(2A) receptor function by interacting proteins. New targets for Huntington’s disease / Modulación de las funciones del receptor A2A de adenosina por interacción con otras proteínas. Nuevas dianas para la enfermedad de Huntington.
In this dissertation we studied the pharmacological and functional consequences of adenosine A2A receptor interaction with other proteins, as other neurotransmitter receptores localized in the human brain and an important ...
Modulation of Amyloid-β peptide aggregation and neurotoxicity in Alzheimer's disease
Aggregation of the amyloid-β (Aβ) peptide to form oligomers and amyloid fibrils is a central event in the pathogenesis of Alzheimer’s disease (AD). This thesis aims to provide a better understanding of Aβ toxicity and the ...
Modulation of cellular pathways as a therapeutic strategy in HIV infection
La característica distintiva del síndrome de la immunodeficiència adquirida (SIDA) és la progressiva depleció de la població de cèl·lules T CD4+ en sang i una destrucció massiva d’aquestes cèl·lules en teixit limfoide. Tot ...
Modulation of central and peripheral molecular clocks by proanthocyanidins
Els ritmes circadians permeten als organismes anticipar-se als canvis mediambientals i adaptar el metabolisme al patró d’alimentació i la disponibilitat d’aliments. De fet, les alteracions del ritme circadià provoquen ...
Modulation of GPCR function by heteromerization
Els receptors acoblats a proteïnes G (GPCRs) formen una de les famílies més grans de proteïnes de membrana involucrades en la transducció de senyals. Aquesta família està composta per més de 800 receptors dividits en cinc ...
Modulation of hepatic lipoprotein metabolism by dietary procyanidins
INTRODUCTION<br/>During the past decade, Nutrition research has been subjected to a shift of focus, from epidemiology and physiology to the comprensión of the molecular basis of nutrients actions.<br/>Thus, the new "-omics" ...
Modulation of intestinal immune response by Outer Membrane Vesicles from probiotic and commensal Escherichia coli strains
Gut microbiota play a critical role in maintaining human intestinal homeostasis and host health. Bacterial extracellular vesicles are key players in bacteria-host communication as they allow delivery of effector molecules ...
Modulation of intestinal immune responses by microbiota-derived extracellular vesicles
The gut microbiota establishes dynamic and complex interactions with the intestinal epithelium and the immune system. In this regard, commensal microbiota plays essential role in the development and maturation of the host ...
Modulation of memory persistence and brain connectivity by non-invasive electrostimulation
Auricular transcutaneous vagus nerve stimulation (atVNS) is an evolving non-invasive neuromodulation technology, which is under investigation for therapeutic applications, including cognitive improvement. In this thesis, ...
