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Ara mostrant els elements 41573-41592 de 42829
Unveiling Nanomedicine Using Correlative Super-Resolution and Electron Microscopy
Els tractaments actuals contra el càncer més enllà de la cirurgia inclouen teràpies que tenen un èxit limitat. Això és degut a efectes secundaris greus, que condueixen a una qualitat de vida reduïda i una baixa efectivitat. ...
Unveiling new molecular Opisthokonta diversity : A perspective from evolutionary genomics
Opisthokonta is an eukaryotic supergroup that contains Metazoa, Fungi and their unicellular relatives. Therefore, this group provides an ideal framework to study distinct unicellular-multicellular transitions, among them, ...
Unveiling novel components of the protein complex responsible for cGMP synthesis in retinal photoreceptors: role in cell physiology and disease
In photoreceptor cells of the retina, light triggers a protein G-mediated enzymatic cascade that leads to hydrolysis of cGMP. The drop in cGMP levels causes the closure of cGMP-channel at the plasma membrane, decreasing ...
Unveiling novel functions of the trascriptional repressor HDAC7 in B lymphocyte development
B lymphopoiesis is the result of several cell lineage choices and differentiation steps whose perturbation leads to B cell malignancies. Cellular transitions for B cell generation have been associated with gene activation ...
Unveiling Protein-Substrate Interactions and Conformations that Influence Catalysis in Carbohydrate-Active Enzymes
Enzymes have attracted the attention of chemists and biologists since long ago due to their molecular complexity and tremendous efficiency. They are highly specific catalysts that make chemical reactions possible at mild ...
Unveiling the biological role of stigmasterol biosynthesis in tomato plants
In plants, the sterol biosynthetic pathway leads to the production of a complex mixture of end-products, among which β-sitosterol, stigmasterol, campesterol, and cholesterol are the most abundant ones. Stigmasterol, the ...
Unveiling the Catalyzing Power of Emotional Intelligence over General Intelligence and Learning Performance
La present tesi investiga el paper catalitzador de la intel·ligència emocional (IE) comportamental, sobre la relació entre la intel·ligència general, o g, i l'acompliment en la aprenentatge. La tesi comprèn tres articles ...
Unveiling the molecular and behavioral properties of hindbrain rhombomere centers
Precise regulation of neurogenesis is achieved by differentially allocating the neurogenic competence along the tissue. In the hindbrain proneural gene expression is stereotypically confined in segment boundary-adjacent ...
Unveiling the multifaceted antimicrobial mechanism of action of human host defence RNases
La presente tesis doctoral se encuentra integrada dentro del estudio a gran escala de la estructura-función de las ribonucleasas antimicrobianas humanas. Estas proteínas catiónicas y de bajo peso molecular son secretadas ...
Unveiling the path of Schumpeterian entrepreneurs: Exploring growth aspirations, innovative entrepreneurship, and export orientation
Fent servir l'obra influent de Schumpeter, aquesta tesi doctoral explora el món dels emprenedors schumpeterians que encarnen qualitats visionàries, abraçant el creixement, la innovació i la internacionalització com a ...
Unveiling the Physics of Neutron Stars: A 3D expedition into MAgneto-Thermal evolution in Isolated Neutron Stars with 'MATINS'
Aquesta tesi doctoral investiga a fons l'evolució a llarg termini dels camps magnètics interns i forts que es troben dins de les estrelles de neutrons aïllades, les quals són els objectes magnètics més poderosos de l'univers. ...
Unveiling the Potential: Exploring Gelation Mechanisms in Alginate Beads Crosslinked with Calcium, Copper and Zinc and their Versatile Applications in Agriculture and Biomedicine
La tecnologia d'encapsulació ofereix protecció, estabilitat i una alliberació controlada dels compostos encapsulats. L'alginate és un polisacàrid natural que s'ha aplicat de manera freqüent com a material encapsulant. No ...
Unveiling the Role of BORA in Ovarian Cancer Dissemination: a new potential targeted therapeutic strategy
El càncer d'ovari (CO) és la neoplàsia ginecològica més letal en països desenvolupats, amb una supervivència als 5 anys menor al 30%. Aquest mal pronòstic s'explica, principalment, perquè la majoria de les pacients són ...
Unveiling the role of DXS-Interacting (DXI) proteins in the regulation of plastidial isoprenoid biosynthesis
Chloroplasts provide plants with metabolic pathways that are unique among eu- karoytes, including the methylerythritol 4-phosphate pathway (MEP) for the pro- duction of isoprenoids essential for photosynthesis and plant ...
Unveiling the role of FAIM in the retina: Characterization of the neurodegenerative and functional alterations of a FAIM knockout mouse model and associated molecular mechanisms
Fas Apoptotic Inhibitory Molecule (FAIM) va ser descrita per primer cop com un antagonista de receptors de mort i un regulador de l’apoptosi. Tot i això, durant els últims anys se li ha atribuït nous rols com la modulació ...
Unveiling the role of Her9/Notch pathway in the maintenance of stemness in the hindbrain boundaries
The generation of cell diversity in the embryonic brain relies on the balance between cell proliferation and differentiation. The hindbrain boundary cells specify at the interface between adjacent compartments. Boundary ...
Unveiling the role of Phytochrome Interacting Factor 1 (PIF1) homologs in tomato
La llum és un dels senyals ambientals més importants que influeixen en el cicle de vida de la planta. Les plantes han desenvolupat un conjunt de complexos mecanismes moleculars que detecten canvis en la qualitat i quantitat ...
Unveiling the role of Slc7a7 in hematopoiesis
[eng] Lysinuric Protein Intolerance (LPI) is a rare autosomal recessive disorder caused by mutations in the SLC7A7 gene, which encodes the y+LAT1 transporter. LPI presents a pleiotropic phenotype that varies among patients, ...
Unveiling the therapeutic potential of THC in endometrial cancer
[eng] Endometrial cancer represents the most common cancer arising from the uterine cavity and there is little hope for patients with recurrent or metastatic disease. Prior studies of our group reported autophagy pathway ...
Unveiling viral structures by single-molecule localization microscopy
Influenza A virus is one of the most outstanding human viruses. The major treatments against influenza are small analogues, monoclonal antibodies and vaccines, however, due to the fast mutation of the seasonal influenza ...
