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Characterization of the Armcx/Almc10 gene family function in mitochondrial dynamics and neural development
The Armcx gene cluster arose by retrotransposition from a single Arm-containing gene (Armc10), and by subsequent short-range tandem duplications of a rapidly evolving region of the Eutherian X chromosome. In this work we ...
Characterization of the biological effects of natural compounds against inflammation, metabolic syndrome and cancer
Els productes naturals han sigut àmpliament utilitzats per al tractament i prevenció de moltes malalties. L’objectiu principal d’aquesta tesi ha estat caracteritzar compostos naturals bioactius que podrien ser utilitzats ...
Characterization of the circadian clock function in the control of cell cycle progression to modulate growth in Arabidopsis thaliana
La función circadiana es esencial para el crecimiento y adaptación de las plantas a su entorno. La maquinaria molecular responsable de la generación de ritmos circadianos está basada en la expresión rítmica de genes cuyo ...
Characterization of the DNA methylation patterns of chemosensitive and chemoresistant human cancer cells: Biological and clinical impact
Although chemotherapeutic drugs are widely used in order to improve the cancer outcome, drug resistance remain the most unpredictable factor affecting chemotherapy and a major impediment to successful patient’s treatment. ...
Characterization of the enzymes involved in the diolsynthase pathway in Pseudomonas aeruginosa
In 2015 our research group described, in P. aeruginosa, the oleate-diol synthase system which consists of two sequentially and independently enzymatic reactions: 10S-Dioxygenase (10-DOX) (PA2077) used oleic acid (as preferred ...
Characterization of the fas death receptor antagonist in the nervous system, lifeguard (LFG)
La activación del Receptor de Muerte Fas, también llamado APO-1 o CD95, da lugar a la formación del Death Inducing Signaling Complex (DISC). Este complejo proteico contiene FADD y caspasa-8, entre otras proteínas, y causa ...
Characterization of the functional connection between the BROMODOMAIN and EXTRATERMINAL DOMAIN PROTEIN 9 (BET9) and the circadian clock in Arabidopsis thaliana
The circadian clock is an endogenously generated timekeeping mechanism that generates 24-hour rhythms in multiple biological processes. The rhythmic oscillations provide an adaptive advantage, allowing organisms to anticipate ...
Characterization of the Hox patterning genes in acoel flatworms
One of the main issues in animal evolution deal with the transition from radial organisms (Cnidaria and Ctnenophora), with only one axis of symmetry, the Oral-Aboral (OA) axis, to bilateral organism (Bilateria), bearing ...
Characterization of the human sperm centrosome and its role in (in)fertility
The centrosome is an essential organelle for the development of a new organism in animals. Upon fertilization the spermatozoon enters into the oocyte providing its basal body that converts into the first centrosome of the ...
Characterization of the Iberian pig genome and transcriptome using high throughput sequencing
En aquesta tesis, hem estudiat els patrons de variabilidad nucleotídica del genoma del porc per entendre millor quines forces evolutives l’han afectat. El porc domèstic és una espècie domèstica que presenta una gran ...
Characterization of the in vivo functions of PrimPol, a novel TLS primase-polymerase
We have identified PrimPol, a yet uncharacterized protein that can act in vitro as a low processivity polymerase able to bypasses thymine dimers in DNA. PrimPol localizes to both the nucleus and mitochondria. In order ...
Characterization of the in vivo immunomodulatory properties of CD5 and CD6
Our goal in this doctoral thesis was to study the immunomodulatory effects of CD5 and CD6, two proteins expressed on the lymphocytes membrane. These two proteins belong to the Scavenger Receptors Cystein- Rich superfamily, ...
Characterization of the infection mechanism during cell-to-cell transmission of HIV-1
La transmissió cèl·lula a cèl·lula del VIH-1 és un mecanisme altament eficient de disseminació viral, i la seva rellevància durant la difusió in vivo en els llocs actius de replicació, és a dir, en els teixits limfoides ...
Characterization of the longitudinal shear strength in composite slabs
The concrete-steel composite slabs show a complex structural characterization due to the different behaviours at the two materials. The materials are exposed to different deformations, large deflections and complex stresses ...
Characterization of the maize protein ZmSTOP1 and its role in drought stress response
El déficit hídrico se ha convertido un una gran amenaza hacia la producción agrícola en todo el mundo. La identificación de nuevos actores en la respuesta al estrés por sequía en plantas cultivables es vital para entender ...
Characterization of the mechanisms underlying alterations in macroautophagy and survival signalling in Huntington’s disease
La malaltia de Huntington és un trastorn neurodegeneratiu progressiu causat per una expansió de repeticions del triplet CAG (més de 37) en l’exó 1 del gen de la huntingtina que genera una proteïna aberrant. Aquesta proteïna ...
Characterization of the micro-substructure of a rural population from the Pyrenees from a geodesic and technical point of view using NGS data : Quantification of batch effects in whole genome sequence data
In this work we present a new whole genome sequencing dataset with samples gathered from the Spanish Eastern Pyrenees (SEP) with more than 40x coverage. We apply both classical and new methods to unveil their particular ...
Characterization of the molecular mechanisms used by JmjC-lysine demethylases to regulate gene expression
The thesis objectives resulted from previous work from Dr Martínez-Balbás lab that characterized the cooperation between TGFβ and JMJD3 to regulate transcription at enhancers, promoters, and gene bodies.Taking into ...
Characterization of the movement of a circadian protein in the temperature-dependent root synchronization of Arabidopsis thaliana
El rellotge circadià està sincronitzat per senyals mediambientals externes, principalment la llum i la temperatura. Entendre com respon el rellotge circadià de la planta a les oscil·lacions de temperatura és crucial per ...
Characterization of the prevention and care cascade in children living with HIV in the Manhiça district, Mozambique
[eng] INTRODUCTION Children acquire human immunodeficiency virus (HIV) infection mainly due to vertical transmission (VT) from their mothers, during pregnancy, delivery or breastfeeding (1). Without immediate access to ...
