Mostrando ítems 29612-29631 de 42921
Vert Company, Anna (Fecha de defensa: 2014-07-30)
Cytotoxic ribonucleases are promising agents to be used in the treatment of cancer. Our group previously described a cytotoxic human pancreatic ribonuclease variant, named PE5, which carries a nuclear localization signal. ...
Pigrau Pastor, Marc (Fecha de defensa: 2018-11-28)
El estrés psicosocial es uno de los grandes problemas de salud en las sociedades modernas. En condiciones fisiológicas el estrés representa una amenaza para la homeostasis. En respuesta al estrés se genera una respuesta ...
Castro Arnau, Júlia (Fecha de defensa: 2023-10-23)
The molecular mechanisms regulating sperm differentiation (spermiogenesis) and maturation in fishes are largely unknown. In these oviparous species, the initiation of sperm motility is triggered by the osmolality of the ...
Català Moll, Francisco (Fecha de defensa: 2020-06-08)
Epigenetic factors, such as histone post-translational modifications and DNA methylation, are critical determinants of gene expression, which ultimately defines cell identity and function. Despite intense research in DNA ...
Calls Cobos, Aina (Fecha de defensa: 2021-06-29)
La neuropatia perifèrica induïda per platins (NPIP) és un dels efectes adversos més freqüents del cisplatí, l’oxaliplatí i el carboplatí, agents quimioteràpics de tipus platins administrats pel tractament de càncers altament ...
Pijuán Jiménez, Isabel (Fecha de defensa: 2019-12-02)
During the process of corticogenesis, cortical radial glial cells (RGs) generate sequentially most of the distinct types of neurons and glial cells that will populate the neocortex. The generation of these cells at the ...
Sala Hojman, Ada (Fecha de defensa: 2016-07-15)
LIF is a pleiotropic cytokine that can act as an immunomodulatory factor in different biological processes, such as embryo implantation, organ transplantation tolerance and multiple sclerosis. Here, we have observed that ...
Fermoselle Pérez, Clara (Fecha de defensa: 2012-11-26)
Muscle dysfunction and muscle wasting are major systemic manifestations of chronic conditions such as Chronic Obstructive Pulmonary Disease (COPD) and cancer. Several biological mechanisms contribute to such a dysfunction. ...
Konstantinidou, Valentini (Fecha de defensa: 2010-03-22)
The scope of the present work was to investigate whether the protective role of the traditional Mediterranean diet (TMD), and virgin olive oil (VOO) rich in phenolic compounds (PC), towards cardiovascular disease can be ...
Vasileva Ilieva, Ekaterina (Fecha de defensa: 2009-05-12)
La hipòtesi de treball d'aquesta tesi es que les malalties neurodegeneratives<br/>poden considerarse formes accelerades de l'envelliment, selectives per a<br/>determinades localitzacions anatòmiques del teixit nerviós. ...
Vigevani, Luisa (Fecha de defensa: 2016-11-21)
RNA splicing is the process of removal of introns from pre-mRNAs. It is carried out by the spliceosome, composed of five small nuclear ribonucleoproteins (snRNPs). Several small molecules with antitumor properties target ...
Gomes Monteiro Lopes Baptista, Maria João (Fecha de defensa: 2012-10-10)
Glucocorticoids are frequently included in the chemotherapy regimens administered to patients with CLL because they are potent immunosuppressant agents and because they are able to induce apoptosis in CLL cells. Although ...
Moncunill Massaguer, Cristina (Fecha de defensa: 2015-07-23)
The pro-apoptotic effects of two new drugs have been studied for the development of new strategies for cancer treatment. On the one hand, we proved that AICAR induces apoptosis in an AMPK- and p53-independent manner in ...
García Beyaert, Marina (Fecha de defensa: 2016-01-27)
Regulation of msl2 translation is a key step in the modulation of X-chromosome dosage compensation. MSL2 is the limiting subunit of the dosage compensation complex, an assembly that promotes hyper-transcription of the ...
Torres Montilla, Salvador (Fecha de defensa: 2022-02-25)
Los carotenoides son isoprenoides que tanto los organismos fotosintéticos como algunos no fotosintéticos producen. Tienen funciones relacionadas con la fotosínte sis, la fotoprotección, la señalización y la pigmentación. ...
Castel Morales, Pau (Fecha de defensa: 2016-05-09)
The development of high-throughput sequencing technologies has prompted the evaluation of large cohorts of different tumor types. The results from these comprehensive genomic studies have revealed the most commonly mutated ...
Pedrosa, Leire (Fecha de defensa: 2020-10-30)
[cat] El glioblastoma (GBM) és el tumor primari cerebral més freqüent i més agressiu. Els pacients amb GBM tenen una supervivència mitjana de 15 mesos. Una dels principals dificultats que presenten els GBMs per ser tractats ...
Solé-Soler, Roger (Fecha de defensa: 2023-12-04)
Els cromosomes han de ser manipulats amb compte per mantenir la integritat del genoma. La família de complexos proteics SMC contribueix a organitzar el genoma en llaços de cromatina, utilitzant la seva activitat d'ATPasa ...
del Ser Badia, Anna (Fecha de defensa: 2022-11-11)
La remodelació sinàptica depenent d’activitat o plasticitat sinàptica és considerada la base cel·lular de diferents processos fisiològics cerebrals com l’aprenentatge i la memòria. Un proteoma equilibrat és essencial per ...
Gamez Molina, Beatriz (Fecha de defensa: 2015-12-17)
We propose a molecular description of the mechanism whereby the osteogenic master gene Osx is controlled post-transcriptionally through a mechanism driven by miR-322/Tob2, strongly suggesting that control of specific mRNA ...