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Functional genomics of wound healing in drosophila = Genòmica funcional del procés de cicatrització en drosophila
La ciencia básica ha de engarzarse con las necesidades sociales. Así, nuestro laboratorio esta involucrado en identificar genes específicamente modulados durante el proceso de cicatrización mediante estudios transcriptómicos ...
Functional impact of alternative splicing in vertebrate proteomes across tissues and cell types
Alternative splicing (AS) is a post-transcriptional mechanism for gene expression regulation affecting almost every multiexonic gene in mammals. However, the impact of AS at the proteomic level remains under debate. In ...
Functional impact of frequent cancer mutations in the splicing regulatory protein RBM10 and discovery of cancer relevant targets
The splicing regulatory protein RBM10 is frequently mutated in bladder carcinomas. Analysis of RNA sequencing data of 476 bladder tumours (UROMOL) identified 469 alternative splicing (AS) events associated with RBM10 ...
Functional impact of polymorphic inversions in the human genome
Una inversió és una reordenació genòmica que altera l'orientació d'una seqüència genòmica específica. Les inversions són reordenaments balancejats i no impliquen necessàriament un guany o pèrdua d'ADN, però tot i així poden ...
Functional implications of protein kinase CK2 in F-actin dynamics and in the cross-talk between auxin and salicylic acid signalling pathways in arabidopsis thaliana
El objetivo de esta tesis era el estudio del papel de la proteina CK2 en tres procesos biológicos de plantas, utilizando Arabidopsis thaliana como modelo: fototropismos, regulación de las vías de señalización del ácido ...
Functional interactions of Infralimbic-Cerebellum pathways in cocaine-induced preference memory
The present thesis investigates the cerebellum-IL interactions in drug-induced memories and their anatomical pathways. To do so, we 1) assessed activity and perineuronal nets (PNNs) expression in the posterior cerebellum ...
Functional interplay between ER and MAF transcription factors in breast cancer bone metastasis
Metastatic breast cancer (BCa) is the leading cause of death in BCa patients. Current therapies for BCa aim at cell proliferation and, therefore, latent disseminated cells are able to escape treatment. For this reason, ...
Functional interplay of two SWI/SNF chromatin-remodeling accessory subunits during C. elegans development
El complexos SWI/SNF són remodeladors de cromatina dependents d’ATP que es troben altament conservats al llarg de l’evolució. Aquests complexos poden regular l’accessibilitat a una zona genòmica alterant l’estat de la ...
Functional interplays of proteins and proteases: AD13-VWF, TGFβ2-α2M, and the proteolysis of gliadin by neprosin
The present thesis has established a new and state of the art mammalian protein expression system at the laboratory which has then contributed with high-yield expression for the purification and crystallization of three ...
Functional Nanomaterials from the Bottom-up Assembly of Colloidal Nanoparticles. A Strategy Towards Efficient Thermoelectrics
The work developed during this PhD has embraced several topics that I divide in three blocks. Each block contains two chapters in this dissertation. Additionally, a general introduction of the different topics is provided ...
Functional oligonucleotide recognition nanomodules for electrochemical DNA biosensors
The goal of this thesis has been to design, characterise and optimise an electrochemical DNA sensor array. In order to investigate the oligonucleotide probe immobilisation and the hybridisation detection, preliminary ...
Functional organization and networ resilience in self-organizing clustered neuronal cultures
Major dynamical traits of a neuronal network are shaped by its underlying circuitry. In several neurological disorders, the deterioration of brain's functionality and cognition has been ascribed to changes in the topological ...
Functional oxide films and interfaces: ferroelectric BaTiO3 films on Si(001) and conducting (110) and (111) LaAlO3/SrTiO3 interfaces
La tesis aborda la integración monolítica de óxidos funcionales sobre silicio y la exploración de intercaras entre SrTiO3(110), SrTiO3(111) y otros óxidos En primer lugar la tesis detalla la integración monolítica del ...
Functional performance in physically frail community dwelling older adults
En països desenvolupats, la característica demogràfica actual més rellevant és l'envelliment de la població. Tenint en compte el percentatge de gent gran i la tendència de la població en el futur, es considera essencial ...
Functional Profiling of PIF3 Regulated Genes in the Dark / Análisis funcional de los genes regulados por PIF3 en oscuridad
After germination in darkness, Arabidopsis seedlings follow a dark specific developmental pattern called skotomorphogenesis or etiolation, characterized because the plant develops long hypocotyls together with a closed ...
Functional profiling of the human gut microbiome using metatranscriptomic approach
Fins ara, les aproximacions meta-òmiques utilitzen tecnologies de seqüenciació d'alt rendiment, que produeixen una quantitat enorme de dades, desafiant així els ordinadors moderns actuals. Hem desenvolupat una nova pipeline ...
Functional properties and applications of plasma polymerized hexamethyldisiloxane (ppHMDSO) thin films
Plasma Polymerization is a novel technique for the preparation of polymer-like thin film coatings at low temperatures onto almost any type of substrates: plastic, metal, semiconductors, wood, textile fibers or membranes, ...
Functional responses of pre- and postsynaptic dopamine D2 receptors in rat brain striatum
El sistema dopaminèrgic has estat molt estudiat en els darrers anys, principalment degut a la seva implicació en diverses patologies com la malaltia de Parkinson, la esquizofrènia o la síndrome de Tourette, així com també ...
The functional role of emergent macrophytes in nature-based solutions (NBS) aiming to mitigate nutrient loading in freshwater ecosystems
Freshwater degradation has been largely attributed to excess nutrient concentrations of anthropogenic origin. Freshwater degradation in combination with water scarcity are the reason of severe stress on water resources ...
