Browsing by Title
Now showing items 28224-28243 of 41771
Mitochondrial and autophagic alterations in human-derived cell models of Parkinson's disease related to LRRK2 (G2019S) and GBA (N370S) mutations
Parkinson's disease (PD) is the second most common neurodegenerative disease, and the most common movement disorder in the world population. In most cases its aetiology is still unknown, however, mitochondrial alterations ...
Mitochondrial and cell cycle functions of SLIMP
The mitochondrial Seryl-tRNA Synthetase (SerRS2) is a member of the class II tRNA synthetase family. The mature enzyme catalyses the ligation of serine to tRNASer in mitochondria. During the process of constructing a model ...
Mitochondrial disorders in childhood: from general characteristics to new aspects
Las enfermedades mitocondriales pueden ser englobadas dentro de las enfermedades raras de la edad pediátrica. Esta tesis recoge aspectos clínicos, bioquímicos y genéticos de 241 pacientes con enfermedades mitocondriales ...
Mitochondrial dynamics and quality control mechanisms in Huntington's disease
[spa] La enfermedad de Huntington (EH) es una enfermedad neurodegenerativa hereditaria causada por la mutación de la huntingtina (mHtt) que ocasiona síntomas motores, cognitivos y psiquiátricos. La característica ...
Mitochondrial dynamics as a hub in the control of muscle inflammation
Some forms of mitochondrial dysfunction induce sterile inflammation through mitochondrial DNA (mtDNA) recognition by intracellular DNA sensors. However, our understanding of the processes operating this activation is ...
Mitochondrial functionalism in HIV-infected children receiving antiretroviral therapy
It is widely known that HIV and ARV drugs trigger mitochondrial impairment in adults. However, their effects in perinatally-infected children have been poorly explored. For this reason, the main hypothesis of the present ...
Mitochondrial implication in intrauterine growth restriction and cardiovascular remodelling
Intrauterine growth restriction (IUGR) is an obstetric complication characterized by placental insufficiency and secondary cardiovascular remodeling that may lead to cardiomyopathy in adulthood. Its etiology and potential ...
Mitochondrial profile and amyloidogenic molecules in sporadic inclusion body myositis
Sporadic inclusion body myositis (sIBM) is the most common myopathy in elderly. This disease causes muscle wasting with both distal and proximal affectation. Quadriceps and finger flexors are muscle typically affected. At ...
Mitochondrial quality control in neurodegenerative diseases: focus on Parkinson’s disease and Huntington’s disease
Darrerament s’han produït avanços importants que han contribuït al coneixement dels mecanismes de disfunció cel·lular i mort en la malaltia de Parkinson (MP) i en la malaltia de Huntington (MH). Ambdues malalties són ...
Mitosis based speculative multithreaded architectures
In the last decade, industry made a right-hand turn and shifted towards multi-core processor designs, also known as Chip-Multi-Processors (CMPs), in order to provide further performance improvements under a reasonable power ...
Mitosis exit regulation by Cdc5 and PP2A-Cdc55
In this thesis we studied the role of PP2ACdc55 in the cytokinesis regulation and the contribution of Cdc5 kinase in the mitosis exit using budding yeast as model. Previously, it was suggested a putative PP2ACdc55 role in ...
Mixed finite element formulations for strain localization and failure in plasticity
Strain localization and quasi-brittle failure in frictional-cohesive materials is still an open and challenging problem in computational mechanics. Owing to its complexity and the significant implications on numerous ...
Mixed finite elements with independent strain interpolation for isotropic and orthotropic damage
The numerical modelling of fracture has been an active topic of research for over five decades. Most of the approaches employed rely on the use of the Finite Element Method, which has shown to be an effective and cost-efficient ...
A Mixed Methods Approach to Identity, Investment, and Language Learning in Study Abroad: The Case of Erasmus Students in Finland, Romania, and Catalonia
La recerca al voltant de l'impacte de les estades a l'estranger sobre la identitat i de la relació entre l'estudi a l'estranger, la identitat i l'aprenentatge d'idiomes, majoritàriament duta a terme mitjançant mètodes ...
Mixed models and point processes
The main objective of this Thesis is to model the occurrence of wildfires and, in particular, knowing the factors with more influence, to evaluate how they are distributed in space and time. The Thesis presents three major ...
Mixed neurodegenerative dementia: the coexistence of dementia with Lewy bodies and Alzheimer´s disease: Expanding our knowledge about the interaction of brain proteinopathies
La demència amb cossos de Lewy (DCL) és la segona causa més freqüent de demència neurodegenerativa, i un alt percentatge de casos mostra copatologia amb la malaltia d’Alzheimer (EA). Els pacients amb DCL i EA concomitant ...
Mixed quantum and classical simulation techniques for mapping electron transfer in proteins
El objetivo de esta tesis se centra en el estudio de la transferencia de electrones (ET), una de las reacciones más simples y cruciales en bioquímica. Para dichos procesos, obtener informaci ...
Mixed Reality Human-Robot Interface for Robotic Operations in Hazardous Environments
This thesis addresses the need for reliable and immersive human-robot interfaces in hazardous environments. Three key goals were achieved. Firstly, techniques were developed to provide immersive interactions while ensuring ...
Mixed-signal alternate test and binning using digitally encoded signatures
Integrated circuit industry has always faced the necessity of testing and verifying the fabricated ICs in order to guarantee that no faulty circuits reach the market as well as the fabricated devices function within design ...
Mixing and chemical reaction hotspots in saline-freshwater mixing zones
Seawater intrusion presents one of the most unique and ubiquitous groundwater problems in the field of hydrogeology. Its complex boundary conditions coupled with variable density flow results in non-uniform flow which lead ...
