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Now showing items 40626-40645 of 41845
Unveiling the role of FAIM in the retina: Characterization of the neurodegenerative and functional alterations of a FAIM knockout mouse model and associated molecular mechanisms
Fas Apoptotic Inhibitory Molecule (FAIM) va ser descrita per primer cop com un antagonista de receptors de mort i un regulador de l’apoptosi. Tot i això, durant els últims anys se li ha atribuït nous rols com la modulació ...
Unveiling the role of Her9/Notch pathway in the maintenance of stemness in the hindbrain boundaries
The generation of cell diversity in the embryonic brain relies on the balance between cell proliferation and differentiation. The hindbrain boundary cells specify at the interface between adjacent compartments. Boundary ...
Unveiling the role of Phytochrome Interacting Factor 1 (PIF1) homologs in tomato
La llum és un dels senyals ambientals més importants que influeixen en el cicle de vida de la planta. Les plantes han desenvolupat un conjunt de complexos mecanismes moleculars que detecten canvis en la qualitat i quantitat ...
Unveiling the role of Slc7a7 in hematopoiesis
[eng] Lysinuric Protein Intolerance (LPI) is a rare autosomal recessive disorder caused by mutations in the SLC7A7 gene, which encodes the y+LAT1 transporter. LPI presents a pleiotropic phenotype that varies among patients, ...
Unveiling the therapeutic potential of THC in endometrial cancer
[eng] Endometrial cancer represents the most common cancer arising from the uterine cavity and there is little hope for patients with recurrent or metastatic disease. Prior studies of our group reported autophagy pathway ...
Unveiling viral structures by single-molecule localization microscopy
Influenza A virus is one of the most outstanding human viruses. The major treatments against influenza are small analogues, monoclonal antibodies and vaccines, however, due to the fast mutation of the seasonal influenza ...
Unweaving complex reactivity: graph-based tools to handle chemical reaction networks
La informació a nivell molecular obtinguda mitjançant estudis "in silico" s’ha establert com una eina essencial per a la caracterització de mecanismes de reacció complexos. A més, l’aplicabilitat de la química computacional ...
Update urban basemap by using the LiDAR mobile mapping system : the case of Abu Dhabi municipal system
Basemaps are the main resource used in urban planning and in building and infrastructure asset management. These maps are used by citizens and by private and public stakeholders. Therefore, accurate, up-to-date geoinformation ...
Updated clinical guidelines: improving their methods and reporting
Antecedentes: Las guías de práctica clínica (GPC) tienen como objetivo orientar en la toma de decisiones a profesionales de la salud, pacientes y responsables de elaborar políticas sanitarias, mediante recomendaciones ...
Updating the current dichotomic “I” classification of metallothioneins to a new “Y” setting: Differentiation between genuine Zn- and Cd-thioneins
La classificació de proteïnes és una eina útil per caracteritzar proteïnes acabades de descobrir. En comparar la seva estructura tridimensional amb altres proteïnes ben caracteritzades, se’n pot inferir la seva funció. No ...
Upgrade paths from existing copper-based access solutions to advanced a gile wavelength-routed passive optical networks
Aquesta tesi presenta un pla de millores des de les xarxes d'accés existents basades en coure a xarxes de fibra òptica fins la llar de segona generació basades en xarxes òptiques passives per enrutament de longitud ...
Upper Palaeolithic rock art of the Italian peninsula. A general review, reframing it into an Euro- Mediterranean context
La present tesi constitueix una investigació sistemàtica sobre l'art rupestre paleolític a la Península Italiana, inserint-lo en el més ampli debat a nivell euromediterrani i oferint un suport vàlid per futures recerques ...
Upscaling mixing-limited chemical reactions from pore to continuum scale using the dispersive lamella concept
Reactive transport modeling is an important tool for the analysis of coupled physical, chemical, and biological processes in Earth systems. Observed reactive transport in heterogeneous porous media shows a different behavior ...
Uptake and metabolism of the antiepileptic drug carbamazepine in plants and role of endophytic bacteria
Nuestro medio ambiente y reservas de agua reciben cada vez más productos de cuidado personal y fármacos. A pesar de una parcial degradación, algunos de estos compuestos presentan una eficiencia de eliminación muy baja en ...
Uptake and metabolization of antibiòtics in crops
The discovery of antibiotics (ABs) and their mass production brought a revolution in medicine worldwide during the middle of the XX century. Infectious diseases with high morbidity and mortality suddenly become treatable. ...
An upwind cell centred finite volume method for large strain explicit solid dynamics in OpenFOAM
In practical engineering applications involving extremely complex geometries, meshing typically constitutes a large portion of the overall design and analysis time. In the computational mechanics community, the ability to ...
Urban agriculture in the framework of sustainable urbanism
L'urbanisme sostenible promou el desenvolupament d'estratègies amb l’objectiu de la sostenibilitat del territori. Una d'aquestes estratègies és l'agricultura urbana (AU). Específicament, els hivernacles en cobertes o terrats ...
Urban cemetery biophilic integration for human well-being : an applied case study of Tehran, Iran
Cemeteries are an ancient reality, and while their basic function has not changed, their physical layout as well as the symbolic and emotional role within our societies has undergone profound transformations over time. The ...
Urban co-creation: community planning, bottom-up and participation tools
For whom do we transform our built environment? The answer may seem obvious, since architecture, in theory, is conceived for humans and for the emancipation of communities. However, it is clear that architecture has moved ...
