Browsing Universitat de Barcelona by Title

Nous reactius d’acoblament per a la síntesi de pèptids basats en 2-ciano-2-hidroxiimino acetat d’etil (Oxyma) com a additiu

Subirós Funosas, Ramon (Date of defense: 2011-07-21)

Els pèptids són biopolímers naturals amb una importància cabdal en el cos humà, actuant com a neurotransmissors, endorfines o hormones. Recentment, s’han descobert propietats molt interessants de pèptids amb aplicacions ...

Nous textos d'historiadors musulmans referents a la Catalunya medieval (continuació de l'obra de J. Mª Millàs i Vallicrosa)

Bramon Planas, Dolors (Date of defense: 1998-12-17)

L'any 1922 Josep Ma Millàs i Vallicrosa publicà "Els Textos d'historiadors musulmans referents a la Catalunya Carolíngia" ("Quaderns d'Estudi", Barcelona, XIV, 125-161). Aquest treball constituia una síntesi de la seva ...

Nova preparació pediàtrica per al tractament de la tuberculosi

Mercadé Frutos, Débora (Date of defense: 2018-12-13)

La tuberculosi és una infecció bacteriana causada per un micobacteri anomenat Mycobacterium tuberculosis. Actualment és la primera causa mundial de mortalitat causada per un agent infecciós fins i tot per sobre de la ...

Nova síntesi d'interès industrial d'un fàrmac genèric

Tolrà Rovira, Roser (Date of defense: 2017-07-21)

L'objectiu principal d'aquesta Tesi doctoral ha estat l’obtenció d’una via alternativa a les existents per a l'obtenció d'un intermedi clau, 1, en la síntesi d'un fàrmac anticoagulant. La nova via havia de ser novedosa i ...

Novel Antimicrobial Agents and Therapeutic Approaches for Nosocomial pneumonia Caused by Pseudomonas aeruginosa

Motos Galera, Ana (Date of defense: 2022-12-21)

[eng] INTRODUCTION: Nosocomial pneumonia caused by Pseudomonas aeruginosa is associated with high mortality and morbidity. Furthermore, the high incidence of multi-resistance to antimicrobials makes both empirical and ...

Novel antimicrobial peptides for therapeutic applications: design, synthesis, characterization, and evaluation of their biological and biophysical activity

Segovia Laserna, Rosario (Date of defense: 2022-03-08)

After decades of exorbitant antibiotic misuse and overuse in human medicine, agriculture and livestock industry, multidrug resistant bacteria (MDR) have become a major medical concern. In this regard, the design of new, ...

Novel approaches to understanding Hent2 and hENT2-related proteins: From novelnuclear variants to global networks / Nuevos enfoques sobre el estudio de hENT2 y proteínas relacionadas: desde nuevas variantes nucleares a redes globales

Grañé Boladeras, Natàlia (Date of defense: 2012-12-21)

hENT2 is the human nucleoside transporter for which most splice variants have been described to date, in contrast to hENT1 for which no variants have been reported yet. In this dissertation, we have identified 3 novel ...

Novel approaches toward anti-Alzheimer and antiprotozoal drug candidates

Sola Lao, Irene (Date of defense: 2016-11-15)

This PhD Thesis pursues the development of novel anti-Alzheimer and antiprotozoal drug candidates upon exploitation of three different novel approaches: Multitarget therapies, Drug repurposing, and Validation of a novel ...

Novel chemical tools for Cancer therapy and imaging: from targeted photoactivatable Pt(IV) complexes to coumarin-based fluorophores and caging groups

Gandioso Ubieto, Albert (Date of defense: 2018-11-12)

In the present Thesis, it has been carried out the development of new chemical tools for the diagnosis and treatment of cancer through the use of light as an external factor. On the one hand, light can be used to control, ...

Novel Disulfide Formation Strategies in Peptide Synthesis

Postma, Tobias Maria (Date of defense: 2014-03-21)

Cysteine (Cys) is a unique amino acid due to its ability to form reversible covalent disulfide bonds. These bonds cause conformational constraints which make peptides or proteins more rigid and stable. In addition, the ...

Novel functions and interactors for Brassinosteroid receptors In Arabidopsis thaliana = Noves funcions i interactors pels receptors de Brassinosteroids d’Arabidopsis thaliana

Fabregas Vallvé, Norma (Date of defense: 2013-09-20)

The general objective of this PhD thesis is to investigate the mechanistic bases for plant hormones Brassinosteroids (BRs) action in plant vascular development. To this end, we have used a multidisciplinary approach by ...

Novel light management techniques for thin film solar cells: Nanotextured substrates and transparent conducting upconverters

Lluscà Jané, Marta (Date of defense: 2015-07-10)

The objective of this work was to study two different light management approaches to enhance the efficiency of thin film Si solar cells and these were the manipulation of the light path (light trapping) and changing the ...

Novel Lipases: Expression and Improvement for Applied Biocatalysis = Nuevas lipasas: expresión y mejoras para biocatálisis aplicada

Infanzón Ramos, Belén (Date of defense: 2017-09-15)

This thesis is focused in the identification and improvement of lipases for biotechnological application. The importance of lipases is increasing in several industries. However, the commercial use of lipases is still a ...

Novel markers and targets of collective tumor cell invasion before and after anti-angiogenic therapies

Sallaberry Pinto, Júlia (Date of defense: 2019-03-22)

Local invasion is a key cell-biological event in the metastatic cascade. In response to a changing microenvironment, cancer cells may act using two main strategies of invasion: single cell invasion and collective invasion. ...

Novel mechanisms and transcription factors involved in the control of stomatal behaviour in Arabidopsis thaliana / Nuevos mecanismos y factores de transcripción involucrados en el control del comportamiento estomático en Arabidopsis thaliana

Legnaioli, Tommaso (Date of defense: 2013-02-26)

The increase in water use efficiency in order to maintain or improve crop yields in times of global warming and progressive reduction of water resources is one of the major challenges faced by agricultural sciences in the ...

Novel methodologies for the conjugation and cyclisation of polyamides

Brun Cubero, Omar (Date of defense: 2016-07-27)

An alternative allowing diene-derivatised polyamides to be used in Diels-Alder conjugation reactions has been explored and developed. In this methodology, conjugation takes place between a fully protected, resin-linked ...

Novel molecular alterations in amyotrophic lateral sclerosis and frontotemporal lobar degeneration spectrum

Andrés Benito, Pol (Date of defense: 2019-12-17)

Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are clinically distinct neurodegenerative diseases that are connected by genetic and pathological overlap. ALS patients present with muscle ...

Novel multi-target directed ligands as drug candidates against Alzheimer’s disease

Pérez Areales, Francisco Javier (Date of defense: 2017-07-14)

Alzheimer’s disease (AD) is the main neurodegenerative disorder and one of the most important health-care problems worldwide, because of its high prevalence and personal and economic impact. To aggravate this situation, ...

Novel nanoscale therapeutic approaches to treat liver diseases

Perramón Corominas, Meritxell (Date of defense: 2022-10-17)

[eng] Chronic liver diseases are one of the most prevalent diseases worldwide. The study of the signaling pathways involved in the fibrogenic process as well as the evaluation of novel therapies such as nanoparticles (NPs) ...

Novel phenotyping and monitoring approaches to assess cereal performance under abiotic stress conditions = Nuevos enfoques de fenotipeado y monitoreo de cultivos para evaluar el rendimiento de cereales cultivados en diferentes condiciones de estrés abiótico

Khaled Elazab, Abdelhalim (Date of defense: 2015-07-13)

Cereals are the basis of the normal diet in most Mediterranean countries and it is estimated that they account for 35-50% of the regional populations’ dietary energy consumption. Water deficit is the main constraint limiting ...