Browsing Universitat de Barcelona by Title

Study of the metabolic reprogramming associated to metastasis in colon cancer

Tarragó Celada, Josep (Date of defense: 2020-09-16)

Metastasis is the main cause of cancer-related deaths and it is of great biomedical importance to develop new therapeutic strategies that specifically target metastatic cells. Therefore, a better comprehension of the process ...

Study of the molecular mechanisms responsible for E2F1-induced Mtorc1 activation

Meo Evoli, Nathalie (Date of defense: 2014-07-07)

The oncogenic properties of E2F1 have been traditionally associated with the role of the oncogene in proliferation, but during the last few years many other functions associated with this family of transcription factors ...

Study of the mTOR pathway in neurodegenerative diseases: from synapses to genes

Martín Flores, Núria (Date of defense: 2018-12-14)

Huntington's disease (HD) and Parkinson's disease (PD) are devastating neurodegenerative diseases that progress with the death of selective neuronal subpopulations. Neuronal dysfunction and death are consequence of multiple ...

Study of the phosphorylation and activation of the protein kinase NEK9 during mitosis

Bertran Domingo, M. Teresa (Date of defense: 2012-11-29)

Nek9 is a NIMA-related kinase that is phosphorylated in mitosis and a small pool of it (5%) is activated at the centrosomes by a complex mechanism which has remained elusive until now. Nek6 and Nek7 bind to the C-terminal ...

Study of the physiological function of carnitine palmitoyltransferase 1C enzyme

Carrasco Rodríguez, Patricia (Date of defense: 2012-03-16)

Carnitine palmitoyl transferase 1 (CPT1) enzymes catalyze the conversion of long-chain acyl-CoA to acyl-carnitines, thus facilitating the entry of long-chain fatty acids to the mitochondria, where they undergo β-oxidation. ...

Study of the Regulatory Mechanisms of Gene Expression in Venous Thromboembolic Disease: microRNAs

Rodríguez Rius, Alba (Date of defense: 2020-10-30)

Venous Thrombosis (VT) is a frequent complex disease that involves a disruption of the balance of the hemostatic system. microRNAs (miRNAs) are small non-coding RNAs that regulate gene expression. Promising findings in ...

Study of the role of substrate stiffness and force transmission to the nucleus in nucleocytoplasmic transport, nuclear pore conformation, genome organization and gene expression

Molina Jordán, Marc (Date of defense: 2023-12-04)

[eng] The application of mechanical force to the nucleus has been recently shown to regulate important functions, including nucleocytoplasmic transport (NCT), chromatin organization, and gene expression. However, how ...

Study of the Secundary Neurulation in the chick embryo, a model to understand neural tube defects = Estudio de la neurulación secundaria en el embrión del pollo, un modelo para entender los defectos del tubo neural

González Gobartt, Elena (Date of defense: 2019-11-29)

Body axis elongation is a hallmark of the vertebrate embryo, which also comprises the morphogenesis of the caudal neural tube (NT). The contribution of bipotential neuromesodermal progenitors (NMPs) to the cranio-caudal ...

A study of the shortwave schemes in the Weather Research and Forecasting model

Montornès Torrecillas, Alex (Date of defense: 2017-02-09)

The radiative transfer cannot be explicitly resolved in the atmospheric models for two reasons: i) a full treatment of the radiative transfer equation (RTE) requires a high amount of computational resources and ii) the ...

Study of the structure-properties relationship of Fe-Al, Nb-Al and Ni-Ti intermetallic coatings obtained by thermal spray technologies

Cinca i Luis, Núria (Date of defense: 2008-12-03)

Due to the current interest on intermetallic compounds (IMCs), specially for their use at high temperatures being capable to substitute superalloys and, for the lately improvement of their lack of ductility, this work ...

Study of transition metal carbide catalysts of group 5 in the RWGS reaction

Pajares Rojas, Arturo Javier (Date of defense: 2021-07-16)

Nowadays there is a growing interest in the capture and utilization of CO2 because of the increase of its concentration in the atmosphere. Captured CO2 can be recycled through different processes to obtain several value-added ...

Study of viscoelasticity and adhesion of human alveolar epithelial cells by atomic force microscopy. The importance of probe geometry

Rico Camps, Félix (Date of defense: 2006-01-27)

During the last century, cellular biology has been mostly assessed from the biochemical point of view: studying how biochemical stimuli modify the biochemical composition of living cells. However, most of the cells that ...

Study on the Connexion 32 and its role in the release of ATP.

Grandes Vilaclara, Mª Eugenia (Date of defense: 2008-06-18)

The aim of this 4 year long work was to study the Connexin32 (Cx32), a protein that forms hemichannels anchored in the plasma membrane. Two hemichannels of adjacent cells form a gap junction. Mutations in Cx32 have been ...

Studying brain development in infants by eye measurements: visual perception and visual attention

Esposito, Flavia Lorena (Date of defense: 2019-12-20)

In the first years of life, there is a dramatic unfolding of cognitive abilities supported by the progressive control of gaze behaviour. The early development of oculomotor control is presumably closely tied to the maturation ...

Studying Electrostatic Polarization Forces at the Nanoscale. Dielectric constant of supported biomembranes measured in air and liquid environment

Gramse, Georg (Date of defense: 2012-06-19)

The objective of my thesis was to develop novel techniques and methods to probe the dielectric properties of biomembranes in air and their natural environment - liquid solution. The dielectric constant ε(r) of biomembranes ...

Studying protein-ligand interactions using a Monte Carlo procedure

Lecina Casas, Daniel (Date of defense: 2017-07-20)

Biomolecular simulations have been widely used in the study of protein-ligand interactions; comprehending the mechanisms involved in the prediction of binding affinities would have a significant repercussion in the ...

Stvdia Carica. Investigaciones sobre la escritura y lengua carias, y su relación con la familia lingüística anatolia indoeuropea.

Adiego, Ignasi-Xavier (Date of defense: 1990-11-09)

El objeto de esta tesis es el estudio pormenorizado de los testimonios lingüísticos del cario, tanto indirectos (glosas y nombres propios) como directos (todo el material epigráfico en alfabeto cario), con una especial ...