Now showing items 9588-9607 of 11089
Roca-Cusachs Soulere, Pere (Date of defense: 2007-02-15)
EN CATALÀ DE LA TESI DOCTORAL<br/><br/>"Importància de l'adhesió al substrat en la mecànica cel·lular: Implicacions en neutròfils i cèl·lules endotelials microvasculars".<br/><br/>En organismes multicel·lulars complexos ...
Alsina Sanchís, Elisenda (Date of defense: 2016-01-21)
Role of TGFβ in physiological angiogenesis and ovarian cancer Transforming Growth Factor Beta (TGFβ) is a signalling pathway involved in a wide range of cellular processes such as proliferation, differentiation, angiogenesis, ...
González Pérez, Laura (Date of defense: 2019-12-12)
The cell cycle is orchestrated by the periodic activation of Cyclin-dependent kinases (CDKs). The enzymatic activity of CDKs depends on their association with cyclins, however, in some cases these kinases can be activated ...
Quesada López, Tania Paloma (Date of defense: 2018-07-09)
Obesity prevalence has tripled in the last fifty years. For this reason, it is considered the pandemic of the century. It is characterized by the accumulation of metabolic abnormalities triggered by an increase in the size ...
Sousa, Nidia de (Date of defense: 2017-07-17)
A successful cell renewal, which occurs throughout the life of an organism, relies on multiple events, including proliferation and differentiation of progenitor cell populations, and death of unnecessary cells. Out of the ...
Pappa, Stella (Date of defense: 2019-04-10)
During neural development, signaling molecules and networks of expressed transcription factors cooperate to control cellular fate. Chromatin acting factors are essential players in cell proliferation and differentiation ...
Corujo Garcia, David (Date of defense: 2019-12-10)
In the eukaryotic cell nucleus, DNA is tightly wrapped around histone complexes, forming a dynamic structure known as chromatin. The nucleosome particle is the basic repeating unit of the chromatin fiber and its protein ...
Banjer, Hamsa Jameel (Date of defense: 2018-07-06)
Transportome alterations have been associated with oncogenesis. The loss of human Concentrative Nucleoside Transporter 1 (hCNT1) during carcinogenesis seems to be a relatively common event in tumors and might by itself ...
Gheitasi, Hoda (Date of defense: 2024-01-26)
[eng] Sjögren Syndrome is a systemic autoimmune disease that affects the exocrine glands, most notably the salivary and lacrimal glands, although it can affect other mucosal surfaces. Inflammation at these sites leads to ...
Sdelci, Sara (Date of defense: 2012-12-13)
This thesis project is focused on the study of the signaling module formed by the NIMA-related protein Nek6, Nek7, and Nek9 and their function during early mitosis, with particular interest in centrosome separation and ...
Herranz Itúrbide, Macarena (Date of defense: 2021-09-23)
[spa] La familia de las NADPH oxidasas ha emergido en los últimos años como una importante fuente de producción de radicales libres de oxígeno (ROS), los cuáles juegan un papel fundamental en situaciones fisiológicas y ...
Crosas Molist, Eva (Date of defense: 2015-02-09)
Reactive oxygen species (ROS) are short-lived, highly electrophilic molecules generated by the partial reduction of oxygen to form superoxide, hydrogen peroxide and hydroxyl radical as well as other secondary metabolites. ...
de la Puente Robles, Beatriz (Date of defense: 2015-12-18)
The present Doctoral Thesis focuses on the study of the sigma-1 receptor (σ1R) in the field of pain. This research has been a part of the preclinical σ1R project focusing on drug discovery of σ1R ligands for the treatment ...
Ferrer Almirall, Mireia (Date of defense: 2012-01-31)
“Plasmodium vivax” és el paràsit causant de malària humana amb més àmplia distribució i és responsable cada any de 100-300 milions de casos clinics, incloent algunes manifestacions severes i mort. P. vivax envaeix principalment ...
Segura Bayona, Sandra (Date of defense: 2018-06-22)
Histone deposition during DNA replication, transcription and repair ensures the faithful maintenance of genetic and epigenetic information. The histone H3-H4 chaperone ASF1 participates in both replication dependent and ...
Pulice, Giuseppe (Date of defense: 2014-12-15)
Changes in diet and life style caused an alarming increase in the incidence of obesity, which is considered a major risk factor for the onset of the metabolic syndrome. One of the initial events in obesity is adipocyte ...
Pi Roig, Aina (Date of defense: 2018-04-06)
Tbx5 is a transcription factor expressed in the developing eyes, heart and upper limbs. Mutations in human TBX5 cause Holt-Oram syndrome (HOS), a condition characterised by heart and upper limb malformations. In zebrafish, ...
Rodríguez Escribà, Marta (Date of defense: 2020-01-21)
Transfer RNAs (tRNAs) are key adaptor molecules that mediate decoding of messenger RNAs (mRNAs) into proteins by complementary pairing of their anticodons with mRNA codons. tRNAs that undergo adenosine to inosine editing ...
Hereu Fina, Bernat (Date of defense: 2007-04-28)
The discipline of ecology is habitually divided up into a whole range of different specialities, and this thesis forms part of what is commonly known as "community ecology" (Diamond and Case 1986). To be more precise, my ...
Zhang, Qing (Date of defense: 2017-09-07)
Vocal learning, one of the subcomponents of language, is put at center stage in this dissertation. The overall hypothesis is that vocal learning lays the foundation for both language evolution (phylogeny) and development ...