Jesús Gil, Carmen de (Date of defense: 2021-06-01)
Psoriasis is a common immune-mediated inflammatory skin condition affecting around 2% of the population worldwide. Different disease subtypes have been described regarding their specific clinical ...
Garrido Charles, Aida (Date of defense: 2020-01-15)
Light-controlled manipulation of neuronal activity has transformed the field of neurobiology. Light provides temporal and spatial resolution over activation or inhibition of targeted populations of ...
Ruiz Arroyo, Víctor Manuel (Date of defense: 2020-10-23)
Zika virus (ZIKV) belongs to the Flaviviridae family and constitute an important public health concern since ZIKV infection produced devastating effects in new born infants. Flaviviruses present a ...
Medina Bernal, Ana del Rocío (Date of defense: 2021-11-19)
Determining and understanding protein structure in atomic detail is a fundamental process to the advancement of biotechnology and biomedicine, shedding light the role of macromolecules and their complexes, ...
Casadó Llombart, Sergi (Date of defense: 2021-12-14)
The immune system comprises cellular and humoral components that protect the organism against external and internal aggressions, such as pathogens and cancer. Therefore, it can distinguish healthy, self ...
Morales Paytuví, Frederic (Date of defense: 2022-02-04)
The following sections of the thesis are divided in two parts corresponding with the two projects conducted, whose objectives are stated below. 1. Caveolin in the endoplasmic reticulum During ...
Jiménez Félix, Alejandro (Date of defense: 2021-01-11)
This thesis is centered on the study of PolyPurine Reverse Hoogsteen (PPRH) hairpins technology as a tool for both gene silencing and gene editing. PolyPurine Reverse Hoogsteen (PPRH) hairpins are ...
Delgado Anglés, Alejandro (Date of defense: 2021-10-25)
Brown and beige adipose tissues are mediators of adaptive energy expenditure in mammals, in contrast with the energy storage role of white fat. Mitochondrial activity, including uncoupled respiration, ...
Bayod Giron, Carles (Date of defense: 2021-05-07)
The nuclear receptors (NR) modulate gene transcription in a ligand-dependent manner throughout different mechanisms. A set of NR, including PPARγ and LXR, are important regulators of carbohydrate and ...
Perez Lopez, Carles (Date of defense: 2022-07-13)
The incremental application of supercomputers to offer solutions to complex problems has motivated the usage of computational modeling tools in drug design pipelines. Specifically, small low-affinity ...