Martínez Campanario, María del Carmen (Date of defense: 2021-05-27)
Macrophages polarization from an inflammatory to a tolerogenic state occurs in both physiological and pathological, and this reprogramming is key in the development of several diseases as different as ...
da Rocha, Pedro Filipe Simões (Date of defense: 2022-11-25)
[eng] Treatment landscape in early-stage NSCLC is rapidly changing after approval of anti-PD-1/PD-L1 in the neoadjuvant and adjuvant settings, respectively. However, biomarkers for patient selection, ...
Feiner Gracia, Natalia (Date of defense: 2020-01-23)
The precise delivery of therapeutic agents to their specific site of action is a big challenge in cancer treatment, which would enhance the efficacy and reduce the side effects of drugs. In this framework, ...
Recalde-Percaz, Leire (Date of defense: 2021-06-30)
Metastases are considered the last stage of tumour progression and the main cause of death associated to solid tumours. There are no effective treatments for metastasis which remain non- curable with ...
Llorente Lope, Alicia (Date of defense: 2021-03-23)
Metastatic breast cancer (BCa) is the leading cause of death in BCa patients. Current therapies for BCa aim at cell proliferation and, therefore, latent disseminated cells are able to escape treatment. ...
Monaco, Paola (Date of defense: 2022-09-23)
[eng] Rhabdomyosarcoma (RMS) is the most prevalent soft tissue sarcoma (STS) in children and adolescents. The Alveolar subtype (ARMS) is driven by PAX3-FOXO1, a fusion protein originated from a chromosomal ...
Martínez Cartró, Míriam (Date of defense: 2021-10-25)
Advances in structural and molecular biology have increased the knowledge of relevant and undrugged targets and have favoured the rational development of novel drugs through structure- based ...
Benítez, Sandra (Date of defense: 2021-01-13)
Receptor activator of nuclear factor kappa-β ligand (RANKL) and its receptor RANK are key mediators of bone resorption1,2. RANKL, its receptor RANK and its natural decoy receptor OPG, which is a competitive ...
Noguera-Castells, Aleix (Date of defense: 2022-01-31)
Modern oncology conceives solid tumours as organs by themselves, meaning that not only should the behaviour of cancer cells to be considered and evaluated therapeutically, but also the so-called tumour ...
Manzano Muñoz, Albert (Date of defense: 2022-12-15)
[eng] Personalized medicine has emerged to improve cancer treatment beyond classical approaches. The identification of genetic mutations by molecular analyses dominate personalized medicine initiatives ...