Kobialka, Piotr (Date of defense: 2020-11-13)
[eng] Our knowledge on the molecular basis behind physiological angiogenesis has significantly expanded in the last two decades. This progress also led to improvement in understanding of many vascular-related ...
Aparicio García, María (Date of defense: 2020-12-09)
[eng] The arrival of antiangiogenic therapies represented a huge advance in the treatment of different tumors, such as renal carcinoma. However, despite initial good results, some tumors were able to ...
Gonçalves Alves, Eliana Carolina (Date of defense: 2021-01-15)
[eng] Neuroblastoma (NB) is the most common extracranial solid childhood tumour. Its clinical and histological manifestations range from benign tumours that spontaneously regress to highly aggressive ...
López Molina, Laura (Date of defense: 2022-06-17)
[spa] La enfermedad de Huntington (EH) es una enfermedad neurodegenerativa hereditaria causada por la mutación de la huntingtina (mHtt) que ocasiona síntomas motores, cognitivos y psiquiátricos. La ...
Dahdah, Norma (Date of defense: 2022-07-27)
[eng] Obesity has become exceedingly pervasive, a resultant of amplified food availability and reshaped human behavior stimulated by urbanization. It poses as a major challenge for human metabolic ...
Martínez Martínez, Arturo (Date of defense: 2022-12-02)
[spa] HERC1 es una E3 ubicuitina ligasa de la familia HECT. Mutaciones en el gen de HERC1 han sido relacionadas con diferentes tipos de cánceres y enfermedades neurodegenerativas. En esta tesis, ...
Loeck, Maximilian (Date of defense: 2022-09-16)
[eng] The blood-brain barrier (BBB) is a major obstacle for the treatment of neurological diseases such as common Parkinson’s disease or rare lysosomal storage disorders (LSDs). LSDs are characterised ...
Ciscar García, Marina (Date of defense: 2022-10-03)
[spa] Durante el proyecto de tesis se han realizado dos proyectos: Por un lado, se ha investigado la biología de la vía de señalización de RANK en adenocarcinomas de mama humanos. Además, se han ...
Caballero Díaz, Daniel (Date of defense: 2018-02-09)
Hepatocellular Carcinoma (HCC) is one of the most common cancers. During hepatocarcinogenesis (a multistep process) there is a disruption of the balance between cell death and survival signalling pathways, ...
Garcia Ferrer, Irene (Date of defense: 2015-12-01)
The balance between proteolytic and antiproteolytic activity is crucial in many biological processes such as nutrition, immune defence, virulence and tissue remodelling. Therefore, it is controlled by ...