Requena Osete, Jordi (Date of defense: 2017-09-08)
Induced pluripotent stem cells (iPSC) can be made from adult somatic cells by reprogramming them with Oct4, Sox2, Klf4 and c-Myc. IPSC have given rise to a new technology to study and treat human disease ...
Jiménez Félix, Alejandro (Date of defense: 2021-01-11)
This thesis is centered on the study of PolyPurine Reverse Hoogsteen (PPRH) hairpins technology as a tool for both gene silencing and gene editing. PolyPurine Reverse Hoogsteen (PPRH) hairpins are ...
González-Ortega, Emmanuel (Date of defense: 2012-07-23)
There are several reasons to celebrate the latest advances in the treatment of the infection with HIV. According to the Joint United Nations Programme on HIV/AIDS, the number of new infections dropped ...
Borgman, Kyra J. E. (Date of defense: 2018-10-26)
Discrimination between foreign and potentially harmful antigens, and the body’s own tissue is one of the most crucial first steps that lays at the basis of a proper immune response. Immunoreceptors are ...
Millán Nebot, Claudia Lucía (Date of defense: 2018-09-21)
Phasing X-ray data within the frame of the ARCIMBOLDO programs requires very accurate models and a sophisticated evaluation of the possible hypotheses. ARCIMBOLDO uses small fragments, that are placed ...
Bayod Giron, Carles (Date of defense: 2021-05-07)
The nuclear receptors (NR) modulate gene transcription in a ligand-dependent manner throughout different mechanisms. A set of NR, including PPARγ and LXR, are important regulators of carbohydrate and ...
Jiménez García, Brian (Date of defense: 2016-07-21)
Computing has pushed a paradigm shift in many disciplines, including structural biology and chemistry. This change has been mainly driven by the increase in performance of computers, the capacity of ...
Cañellas Fontanilles, Marina (Date of defense: 2018-07-17)
It is widely known that the development of modern chemistry and the consequent world industrialization have improved our quality of life to unimaginable levels. However, these advances have come with a ...
Acevedo Lipes, Andrea Milena (Date of defense: 2021-03-09)
Clinical pathologists identify visually many morphological features to characterize the different normal cells, as well as the abnormal cell types whose presence in peripheral blood is the evidence of ...
Quiroga Álvarez, Xarxa (Date of defense: 2021-06-23)
Five years ago, I started walking this path that now seems like an entire life. Although everyone around tried to explain how this would feel, none of their explanations could have match what it has ...