Salamanca Viloria, Juan (Date of defense: 2022-05-27)
Tribbles (TRIB) homologues proteins are a family of three pseudokinases withan important role in controlling immunity, metabolism, and cancer throughprotein-protein interactions (PPIs). TRIB pseudokinases ...
Garcia Cabau, Carla (Date of defense: 2022-05-31)
Intrinsically disordered (ID) proteins or regions are protein sequences that lack stable secondary and tertiary structures. ID proteins are particularly prone to undergo liquid- liquid phase separation ...
Martínez Gutiérrez, Alfredo (Date of defense: 2019-12-13)
One of the main causal factors of skin aging is ultraviolet radiation as part of sun exposure. This radiation induces many changes at the molecular level that alter the proper function of skin biological ...
Rodón Ahnert, Laura (Date of defense: 2012-11-28)
The TGF-β pathway is currently considered a therapeutic target in advanced tumors, including glioblastoma (GBM), and several anti-TGFβ agents are in clinical trials and have shown promising results .A ...
Khojasteh, Abbas (Date of defense: 2019-11-22)
Rosmarinic acid (RA), an ester of caffeic acid and 3,4-dihydroxyphenyl lactic acid, is widely distributed in the plant kingdom, including Satureja khuzistanica, a threatened Iranian plant species. ...
Szulc, Elizbieta Maria (Date of defense: 2020-01-09)
Androgen receptor is a transcription factor that plays a key role in prostate cancer development and progression. Its N-terminal intrinsically disordered activation domain is an example of ill- structured ...
Novoa Pardo, Eva Maria (Date of defense: 2012-12-20)
Gene translation is a central process in all cells, in which messenger RNA (mRNA) is decoded by the ribosome to produce a specific amino acid chain, that will later fold into an active protein. This ...
Aseeri, Mazen (Date of defense: 2023-03-13)
[eng] The main goals of this PhD thesis are closely related within the field of CDases and their key role in the regulation of sphingolipid metabolism. Thus, the roles of ACER3 and AC in different human ...
da Rocha, Pedro Filipe Simões (Date of defense: 2022-11-25)
[eng] Treatment landscape in early-stage NSCLC is rapidly changing after approval of anti-PD-1/PD-L1 in the neoadjuvant and adjuvant settings, respectively. However, biomarkers for patient selection, ...
Solé i Codina, Laura (Date of defense: 2013-12-13)
Voltage gated potassium channels (Kv) play important roles in different biological process such as generation and propagation of the nerve pulse and the cardiac action potential, promotion of insulin ...