Llorente Lope, Alicia (Date of defense: 2021-03-23)
Metastatic breast cancer (BCa) is the leading cause of death in BCa patients. Current therapies for BCa aim at cell proliferation and, therefore, latent disseminated cells are able to escape treatment. ...
Pérez Salvia, Montserrat (Date of defense: 2019-03-01)
Cancer is considered nowadays a genetic and epigenetic disease. Aberrancies in epigenetic marks in DNA and histone tails together with alterations in epigenetic regulators responsible of catalyzing ...
Celià Terrassa, Antoni (Date of defense: 2012-05-14)
This Doctoral Thesis project is part of a broader research program whose global aim is to better understand key molecular and cellular events in tumor metastasis, in particular those associated with ...
Benítez, Sandra (Date of defense: 2021-01-13)
Receptor activator of nuclear factor kappa-β ligand (RANKL) and its receptor RANK are key mediators of bone resorption1,2. RANKL, its receptor RANK and its natural decoy receptor OPG, which is a competitive ...
Noguera-Castells, Aleix (Date of defense: 2022-01-31)
Modern oncology conceives solid tumours as organs by themselves, meaning that not only should the behaviour of cancer cells to be considered and evaluated therapeutically, but also the so-called tumour ...
Casal Domínguez, María (Date of defense: 2018-02-16)
Inflammatory myopathy (IM) is a heterogeneous group of diseases characterized by muscle weakness and inflammatory infiltrates on the muscle biopsy. But muscle involvement is not always present and other ...
López Solà, Clara (Date of defense: 2015-07-24)
There is an incomplete understanding of the heritability and the specific genetic bases of Obsessive-Compulsive Disorder (OCD). It has a complex multifactorial etiology comprising both biological as ...
Royo Garrido, Romina (Date of defense: 2023-03-31)
[eng] Next-generation sequencing (NGS) has revolutionized biomedical sciences, especially in the area of cancer. It has nourished genomic research with extensive collections of sequenced genomes that ...
Manzano Muñoz, Albert (Date of defense: 2022-12-15)
[eng] Personalized medicine has emerged to improve cancer treatment beyond classical approaches. The identification of genetic mutations by molecular analyses dominate personalized medicine initiatives ...
Moreno Monasterio, Marta (Date of defense: 2015-02-18)
The main goal of this PhD thesis was to understand the mechanisms underlying GBM tumor formation and progression, with a special emphasis on the study of factors that have a role in normal NSC biology, ...