Moreta Moraleda, Cristina (Date of defense: 2022-01-25)
The hypothesis of the present thesis is that the presence or absence of some chromatin factors may facilitate or impair the action of chemotherapeutic drugs in colorectal cancer (CRC). Chromatin factors ...
Ciria Suárez, Laura (Date of defense: 2021-11-29)
BACKGROUND: Breast cancer is one of the most prevalent diseases in women. Prevention and treatments have lowered mortality; nevertheless, the impact of diagnosis and treatment continue to affect ...
Montero Martín, Sara (Date of defense: 2021-11-22)
Despite the latest advances in early diagnosis and increased resources employed to develop new therapeutic options, effective control of cancer disease remains a challenge. In fact, cancer is the second ...
Balcells Nadal, Cristina (Date of defense: 2019-12-19)
Metastasis and drug resistance represent the two main causes of therapeutic failure in oncology. In the present dissertation, the interplay between them has been interrogated using metabolomics, systems ...
Almacellas i Canals, Eugènia (Date of defense: 2018-11-21)
Lysosomes are the primary degradative organelles in mammalian cells. Indeed, lysosome enzymatic cocktail allows the degradation of a vast repertoire of cellular material through different converging ...
Amirthalingam, Ezhil (Date of defense: 2018-10-01)
This thesis has its main focus on developing multi-functional nanomaterials, that we called nano- and microtools through two different approaches, top-down to provide support and bottom up to give ...
Arroba Hidalgo, Ester (Date of defense: 2021-02-10)
The human leukocyte antigen-G (HLA-G) is a non-classic MHC class I molecule. It is called “non-classic” because it differs from classic MHC class I molecules due to its very low amount of polymorphism ...
Badia Ramentol, Jordi (Date of defense: 2020-01-14)
Colorectal cancer (CRC) is the second-highest cause for cancer-related mortality worldwide. Patients suffering from CRC generally don’t die from primary tumours but rather from metastasis, for which ...
Riaño Canalias, Ferran (Date of defense: 2017-09-29)
Ribosome biogenesis is one of the most energy consuming anabolic processes in a cell, required for the generation of the translational machinery to grow and proliferate. Moreover, this process necessitates ...
Gutierrez Prat, Núria (Date of defense: 2018-10-03)
Cells often need to respond to damaging internal and external stimuli. One of the pathways that is frequently activated by stress stimuli involves activation of the kinase p38alpha, which can phosphorylate ...