Mostrando ítems 1-10 de 78
Garcia Cabau, Carla (Fecha de defensa: 2022-05-31)
Intrinsically disordered (ID) proteins or regions are protein sequences that lack stable secondary and tertiary structures. ID proteins are particularly prone to undergo liquid- liquid phase separation ...
Sancho Jodar, Ferran (Fecha de defensa: 2019-11-22)
Enzyme catalysis has been scaled up for several industrial sectors during the last decades, including pharmaceutics, food and beverages. This raised the interest of other industries such as energy or ...
Chiesa, Giulio (Fecha de defensa: 2015-12-11)
Spinal bulbar muscular atrophy (SBMA) is a member of the polyglutamine (polyQ) expansion diseases family; the most famous of which is Huntington disease (HD). SBMA is caused by the expansion of the ...
Szulc, Elizbieta Maria (Fecha de defensa: 2020-01-09)
Androgen receptor is a transcription factor that plays a key role in prostate cancer development and progression. Its N-terminal intrinsically disordered activation domain is an example of ill- structured ...
Solé i Codina, Laura (Fecha de defensa: 2013-12-13)
Voltage gated potassium channels (Kv) play important roles in different biological process such as generation and propagation of the nerve pulse and the cardiac action potential, promotion of insulin ...
Escobedo Pascual, Albert (Fecha de defensa: 2014-11-06)
Nedd4L is a HECT-type E3 ubiquitin ligase (it covalently binds ubiquitin molecules before transferring them to the final substrate). Ubiquitination is a posttranslational modification (PTM) that labels ...
Nicolàs i Aragó, Adrià (Fecha de defensa: 2022-12-14)
[eng] L-type amino acid transporters play key roles in human physiology and are involved in several human pathologies such as primary inherited aminoacidurias (Feliubadaló et al., 1999; Torrents et al., ...
González Velasco, Lorena (Fecha de defensa: 2021-09-14)
Non-canonical activation of p38α MAPK has been associated to cardiomyocyte death in several cardiovascular pathologies, such as myocardial ischaemia-reper- fusion injury. Unfortunately, current p38α ...
Garcia Pindado, Júlia (Fecha de defensa: 2017-05-12)
The present thesis is based on the development and optimization of a solid-phase strategy to prepare biaryl bicyclic pentapeptides. Suzuki-Miyaura cross-coupling reactions were used to obtain the biaryl ...
Hernaiz Llorens, Marc (Fecha de defensa: 2019-11-25)
During brain development, UNC5 receptors play a key role in controlling axonal extension through their sensing of the guidance molecule Netrin-1. The correct positioning of receptors into specific ...