Pell Vidal, Núria (Date of defense: 2020-11-19)
Obesity is reaching pandemic dimensions and is an established instigator of many diseases, such as non alcoholic fatty liver disease, the most prevalent liver disease worldwide. Most studies in this ...
Bianco, Valentino (Date of defense: 2013-07-19)
Water is commonly associated with life. This substance affects the living beings in countless aspects and length scales, ranging from molecular biology to climatology. Water exhibits a long series of ...
Quintana Agustí, Mireia (Date of defense: 2019-09-30)
This thesis addresses three different subjects closely related. First, a phenotypic screening measuring cytotoxicity in the gastric cancer cell line HGC-27 is reported. Next, a targeted-based assay ...
Baumann, Adrian (Date of defense: 2018-11-22)
Endocytosis and endosomal trafficking are of central meaning in all eukaryotic cells. It enables cells to rapidly modify their surface exposure of signalling complexes, nutrient and ion transporters, ...
Pérez Cano, Laura (Date of defense: 2013-06-28)
Computational methods are increasingly important to help to predict and characterize protein interactions. However, most of the efforts so far have focused on protein-protein and protein-ligand interactions, ...
Iruela Martin, Guillermo (Date of defense: 2021-09-16)
c-Src tyrosine kinase is associated with poor prognosis in many cancer processes. Although inhibitors of c-Src kinase activity are known, they have not reached success in clinical trials because of lack ...
Rodríguez Nuevo, Aida (Date of defense: 2018-04-12)
Opa1 is a mitochondrial dynamics protein responsible for the fusion of the inner mitochondrial membrane, the maintenance of cristae morphology, and involved in mitochondrial DNA stability. In this study ...
Pozuelo Ruiz, Marta (Date of defense: 2017-07-18)
Electron Transfer (ET) is undoubtedly one of the most important processes in life. Molecularly well-defined ET pathways in complex protein ensembles play a vital role in biological processes such as ...
Palau de Miguel, Anna (Date of defense: 2016-11-30)
Polycomb proteins are important epigenetic regulators involved in the maintenance of stemness and differentiation. In this thesis, I focused on the role of some Polycomb Repressive Complex 1 (PRC1) ...
Capdevila Busquets, Eva (Date of defense: 2016-03-17)
Breast cancer is a very heterogeneous disease with a poor prognostic outcome, largely due to its resistance to current cancer therapies. The balance between cell proliferation and apoptosis plays a ...