Mostrando ítems 1-4 de 4
Garcia Pindado, Júlia (Fecha de defensa: 2017-05-12)
The present thesis is based on the development and optimization of a solid-phase strategy to prepare biaryl bicyclic pentapeptides. Suzuki-Miyaura cross-coupling reactions were used to obtain the biaryl ...
Guardiola Bagán, Salvador (Fecha de defensa: 2017-09-15)
Protein-protein interactions (PPIs) and protein surfaces are considered challenging targets for drug discovery. In this field, conventional medicinal chemistry (i.e. small molecules) has largely failed ...
Díaz Perlas, Cristina (Fecha de defensa: 2018-03-07)
Peptides play a critical role in human physiology and harbour a huge potential as therapeutic agents. In this thesis, new peptides have been discovered as ligands for the epidermal growth factor (EGF) ...
Ciudad Fernández, Sonia (Fecha de defensa: 2016-11-08)
The present thesis is based on the work developed about the use of peptides and small proteins in protein surface molecular recognition. Peptides present several advantages when compared with small ...