Vázquez Jiménez, Laura (Date of defense: 2014-11-25)
Oxidative stress is one of the most important factors in degenerative diseases like cancer, Alzheimer or in episodes like ischemia. During these processes, reactive species of oxygen (ROS) and nitrogen ...
Lafuente Fabra, Maria (Date of defense: 2018-07-18)
The present research project can be included in the broad supramolecular chemistry field that was defined by Nobel laureate Jean Marie Lehn as the "chemistry beyond the molecule".1 It is based on processes ...
Vilaprinyó Pascual, Sílvia (Date of defense: 2015-07-27)
Amyloid-beta protein (Aß) is strongly linked to the aetiology of Alzheimer’s disease (AD). Even though Aß has a central role in AD, this protein is normally produced in healthy humans. It is the aberrant ...
Rodríguez Mías, Ricard Aleix (Date of defense: 2006-10-05)
Nuclear Magnetic Resonance has experienced an increasing interest in the drug discovery field that has led to its wide use on nearly every stage of drug development. For this reason, during the present ...
Romo Fernández, Juan Manuel (Date of defense: 2015-06-22)
In this Doctoral Thesis a new stereoselective Ni(II)–mediated catalytic system for the SN1–like addition of chiral Nacyl thiazolidinethiones to electrophiles able to deliver cationic species under ...
Pelay Gimeno, Marta (Date of defense: 2013-02-15)
Pipecolidepsin A is a cyclodepsipeptide produced by a Homophymia marine sponge that has shown interesting anticancer properties against several human cancer cell lines. From a structural point of view, ...
Góngora Benítez, Miriam (Date of defense: 2013-02-08)
Synthesis of Cys-containing peptides has long been posed as an attractive challenge for peptide chemist. Protecting groups for the nucleophilic beta-thiol group of Cys residues must be stable during ...
Oller Salvia, Benjamí (Date of defense: 2015-05-18)
Brain delivery is a major unmet challenge because most drugs cannot cross the blood-brain barrier (BBB). Despite the restrictive nature of this barrier, brain vasculature reaches essentially every neural ...
Broto Avilés, Marta (Date of defense: 2017-09-18)
La medicina personalitzada esta prenent rellevància últimament. Aquesta es basa en la monitorització simultània de diferents biomarcadors, els biomarcadors poden ser molècules de diferent naturalesa ...
Maffei, Mariano (Date of defense: 2014-11-03)
Objectives: Objective 1 – Effect of mutations perturbing the ULBR of the Unique domain of c-Src. The first objective of this thesis was the in vitro characterization of the effect of mutations in ...