Now showing items 144-156 of 156
Pérez Cano, Laura (Date of defense: 2013-06-28)
Computational methods are increasingly important to help to predict and characterize protein interactions. However, most of the efforts so far have focused on protein-protein and protein-ligand interactions, and few computer ...
Álvarez Marimón, Mª Elena (Date of defense: 2014-10-27)
Heteromeric amino acid transporters (HATs) mediate the transport of amino acids through the plasma membrane. They are composed of two subunits (a heavy and a light one) linked by a conserved disulfide bridge. Genetic defects ...
Carreras Cardona, Anna (Date of defense: 2012-05-04)
During aerobic cell metabolism, molecular oxygen is reduced to water through electron-transfer reactions, and the oxygen not completely reduced is transformed into a set of neutral and free radical molecules with high ...
Tarrado Castellarnau, Miriam Neus (Date of defense: 2015-12-11)
Cancer is characterised by the lost of physiological control and the malignant transformation of cells that acquire functional and genetic abnormalities, leading to tumour development and progression. Colon and lung cancer ...
Toledo Soler, Miriam (Date of defense: 2015-04-21)
La caquèxia és una síndrome clínicament evident en la seva fase avançada ja que es manifesta amb pèrdua substancial de greix i múscul esquelètic. Pels malalts els representa, en aquesta última etapa, una reduïda probabilitat ...
Costa i Torres, Meritxell (Date of defense: 2012-05-04)
Introduction Heteromeric amino acid transporters (HATs) are composed of a heavy subunit (rBAT or 4F2hc) and a light subunit (b0 + AT, ASC1, LAT1, LAT2, y + LAT1, y + LAT2 and xCT), joined by a disulfide bridge (Chillaron ...
Menchon Najas, Cristina (Date of defense: 2011-06-09)
Embryonic stem cells (ESC) are derived from the inner cell mass (ICM) of the blastocyst and have the capacity for unlimited proliferation while retaining their potential to differentiate into a wide variety of cell types ...
Benito Mauricio, Adrián (Date of defense: 2014-02-21)
The present doctoral thesis is focused on the metabolic adaptations induced by oncogene activation as well as the potential role of the metabolic network as antitumor therapy. Over the last years, it has emerged a renewed ...
Valle Álvaro, Elisabet del (Date of defense: 2016-02-09)
Els baixos resultats obtinguts en els indicadors de transferència de tecnologia des de les universitats i centres públics de recerca a empreses a Catalunya indiquen que aquesta no és una tasca fàcil. Tot i que hi la qualitat ...
Ayermich Buch, Ivette (Date of defense: 2006-01-13)
Els transportadors de nucleòsids són fonamentals en la regulació de molts processos fisiològics, modulant els nivells extra- i intracel·lulars dels substrats que internalitzen però a la vegada representen el camí d'entrada ...
Jiménez Vidal, Maite (Date of defense: 2005-01-28)
Los transportadores heteroméricos de aminoácidos (HAT) están formados por una subunidad ligera (LSHAT) y una subunidad pesada (HSHAT) unidas entre ellas mediante un puente disulfuro.<br/><br/>Se han descrito dos HSHATs: ...
Ruiz Paz, Soraya (Date of defense: 2005-05-06)
Un número sustancial de proteínas de transmembrana de la superficie celular sufren un corte proteolítico que conduce a la liberación de su dominio extracelular. Este proceso, conocido como "shedding" (del inglés despojarse ...
García Fuster, M. Julia (Date of defense: 2005-10-07)
Los objetivos principales de esta Tesis doctoral fueron: 1) cuantificar los efectos agudos y crónicos de fármacos opiáceos (mi-, delta- y kappa-selectivos) así como los cambios inducidos durante los estados de abstinencia ...