Universitat Pompeu Fabra
Now showing items 2621-2640 of 3260
Analitzo els rituals a santuaris no monumentals fenício-púnics de la Península Ibérica, Eivissa i Sardenya (ss. VII-II a. C.) tenint en compte la Teoria de la Pràctica (Bourdieu) i la ritualització (Bell). Estudio els ...
Biomolecular condensates act as indispensable membrane-less organelles for intracellular organization and regulation of biochemical reactions. Proteins and RNAs are known to phase separate into condensates, however the ...
Gene dosage alterations of the kinase DYRK1A are linked to disease in humans. To better understand DYRK1A activities an interactome analysis was performed. RNF169, an E3-ubiquitin ligase key component of the cellular ...
La cirugía robótica con el Da Vinci se está convirtiendo en una alternativa cada vez más común para la práctica de procedimientos quirúrgicos en todo el mundo. Este robot no constituye un ejemplo de inteligencia artificial, ...
Intellectual disability encompasses several neurodevelopmental disorders characterized by impairments in cognitive and adaptive functioning with onset during the developmental period. Currently, treatment of intellectual ...
The transition from maternal to embryonic control is a crucial time in an organism’s life cycle, with an overhaul of the epigenetic marks, targeted mRNA degradation and the initiation of transcription. Yet, not only do ...
The incorporation and regeneration of blue spaces in urban areas could promote health in cities. Nevertheless, research on the effects of these spaces is still scarce. This thesis aimed to evaluate the influence of blue ...
Daily time-keeping of tissue functions promotes efficient organ function and systemic metabolic homeostasis, processes integral to life which are subject to decline with aging. To ensure the correct functional coordination ...
The endocannabinoid system is a natural modulatory system that participates in multiple physiological processes, including nociceptive, emotional and rewarding responses. These central responses are mainly mediated by ...
T-cell acute lymphoblastic leukemia (T-ALL) accounts for 10 15% of pediatric ALL. The oncogenic transformation of T-cell precursors is driven by a broad spectrum of genetic abnormalities. We have confirmed the high frequency ...
In our everyday life we must effectively orient attention to relevant objects and events in multisensory environments. The impact of cross-modal links for attention orienting to spatial and temporal cues has been widely ...
Cyclin O, a novel identified CDK1 and CDK2-binding cyclin, has been demonstrated to be required for γ-radiation induced apoptosis in a lymphoid cell line. Ɣ-radiation induces the formation of DSBs in the DNA what activate ...
Synaptic connections in the brain respond throughout their lives to the activity of incoming neurons, adjusting their biological properties to increment activity-dependent changes. Hippocampal neuronal plasticity disruptions ...
In this work we have assessed the possible contribution of the human chromosome-21 gene DYRK1A in the developmental cortical alterations associated with Down Syndrome using the mBACTgDyrk1a mouse, which carries 3 copies ...
In the intestinal epithelium, Wnt signaling drives the expression of the genes encoding tyrosine kinase receptors EphB2 and EphB3 and represses the expression of their membrane-tethered ligands, ephrin-Bs. Eph-ephrin ...
Mi trabajo ha estado enfocado en la implicación de los diferentes mecanismos epigenéticos de PML-RARa en la inducción de la leucemia promielocítica aguda (APL).<br/>En particular yo estudié el rol de MBD1, un miembro de ...
Pancreatic ductal adenocarcinoma (PDA) is one of the most aggressive tumors; mostly due to its lack of symptoms, resulting in late diagnosis, and also due to the presence of an aggressive tumor microenvironment. Importantly, ...
This thesis is a compilation of three articles that aim to contribute to a deeper understanding of the role of higher education in refugees’ integration by focusing on urban refugees’ experiences who settled in a neighboring ...
Epigenetic modification serves as a crucial mechanism in regulating gene expression and facilitating cellular adaptation to environmental stress. This study aimed to identify histone residues and their associated ...
The relevance of epigenetics is increasingly recognized in haematopoietic diseases such as myelodysplastic syndromes (MDS) and acute myeloid leukaemia (AML). Variants of histones, such as macroH2As, and chromatin remodellers, ...
