La UPF és una universitat pública, internacional i intensiva en recerca que està al nivell de les millors universitats europees. Amb excel·lents indicadors de producció científica com és el cas de les tesis doctorals en accés obert.

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Si sou doctor o doctora de la Universitat Pompeu Fabra i voleu publicar la vostra tesi a TDX, contacteu amb CAU . Per a més informació consulteu Publicació de tesis a TDX. i les preguntes més freqüents

Recent Submissions

Integrating computational techniques for enhanced understanding of protein-protein interactions and the human interactome 

Bota, Patricia Mirela (Date of defense: 2024-05-21)

Protein-protein interactions (PPIs) are fundamental in driving biological processes and maintaining life’s diverse functions. They play a key role in cellular regulation, facilitating our understanding of both basic ...

OccRF-Health study: occupational exposure of workers to RF-EMF 

Turuban, Maxime (Date of defense: 2024-05-15)

Radiofrequency electromagnetic fields (RF-EMF) exposure, ubiquitous in our environment due to the rise in mobile phones and wireless technology, has grown significantly in the last 30 years. This exposure is generally ...

Untangling chromatin: investigating the role of transcription, supercoiling and topoisomerases in genome organization 

Martín de Dios, Laura (Date of defense: 2024-05-06)

La organización del genoma en células mamíferas sigue siendo en gran parte desconocida. Un nivel fundamental de organización se considera el bucle de cromatina, que consiste en una región de ADN atrapada en el interior ...

Role of histone modifications in transcription regulation upon environmental stress in eukaryotes 

Bae, Hansol (Date of defense: 2024-04-26)

Epigenetic modification serves as a crucial mechanism in regulating gene expression and facilitating cellular adaptation to environmental stress. This study aimed to identify histone residues and their associated ...

Deciphering B lymphocyte dynamics in health and disease through the integrative analysis of multi-modal single-cell data 

Aguilar Fernández, Sergio (Date of defense: 2024-04-24)

The intrinsic complexity and dynamic nature of B-lymphocytes make them ideal for in-depth analysis using single-cell technologies. Secondary lymphoid organs (SLOs) are central in B-lymphocyte activation and differentiation, ...

Modeling cell type evolution using single-cell and chromatin profiling approaches 

Elek, Anamaria (Date of defense: 2024-04-19)

Single-cell genomics methods have revolutionized the study of gene expression and regulation at the cell type level. Generating single-cell atlases for species at key phylogenetic positions of the animal tree of life (e.g.. ...

Health impacts and determinants of environmental exposures related to urban and transport planning practices in European cities 

Khomenko, Sasha (Date of defense: 2024-04-19)

The rapid increase in urbanization underscores the need for healthy urban environments. Presently, European cities experience high levels of air pollution, noise, lack of green spaces, and increased local temperatures, all ...

Exploring the role of climate variability and change in the spillover of zoonotic diseases: towards the development of Early Warning Systems (RWS) 

San José Plana, Adrià (Date of defense: 2024-04-16)

The primary goal of this PhD is to deepen our understanding and improve the modeling capacity of zoonotic spillover, the multilevel process by which pathogens manage to overcome a series of natural barriers and infect other ...

Experience-dependent information processing in biological systems 

Vidal, María Sol (Date of defense: 2024-04-15)

Organisms need to integrate its previous experience with its current internal state in order to deliver a suitable response to dynamic changes in their environment. This thesis is devoted to analyze, using a mathematical ...

The phenotypic plasticity behind the origin of animals: functional genomics, cell biology, and new genetic tools 

Suárez Ara, Patricia (Date of defense: 2024-04-12)

The origin of animals has puzzled scientists for centuries. The transition from a unicellular eukaryote to animals is undoubtedly one of the biggest evolutionary transitions in Earth’s history. To unravel the evolutionary ...

Hacia una medicina basada en la precisión en entornos de rehabilitación: evaluación del estado nutricional y la sarcopenia en pacientes con enfermedades crónicas = Towards a precision-based rehabilitation medicine: asssessment of nutritional status and sarcopenia in patients with chronic diseases referred to rehabilitation 

Dávalos Yerovi, Natalia Vanesa (Date of defense: 2024-04-12)

Esta tesis aborda la malnutrición y la sarcopenia en pacientes con enfermedades crónicas, centrándose en la enfermedad pulmonar obstructiva crónica (EPOC) y la enfermedad renal crónica. Utilizando los criterios de la Global ...

Characterization of allosteric communication networks in GPCRs 

Morales Pastor, Adrián (Date of defense: 2024-04-11)

G protein-coupled receptors (GPCRs) are central to cellular signaling and pivotal in drug development. This thesis investigates allosteric communication in GPCRs, crucial for their effective modulation in pharmacotherapy. ...

PET in preclinical AD: image harmonization, characterization of the centiloid metric of Aβ load and associations with tau fluid biomarkers 

Shekari, Mahnaz (Date of defense: 2024-04-03)

This thesis explores technical factors influencing brain PET quantification, developing brain PET harmonization framework, assessing Centiloid robustness as a clinical biomarker, and evaluating the associations between ...

Decoding the epitranscriptomic complexity through computational methods based on long-read sequencing 

Delgado Tejedor, Anna (Date of defense: 2024-03-21)

RNA modifications, collectively known as the ‘epitranscriptome’, play a major role in multiple biological processes, including splicing regulation, gene expression regulation and antibiotic resistance. Unfortunately, ...

Development of a low input chromatin profiling technique to examine the role of PRC2 proteins in development and leukaemia 

Sondermann, Nathalie Allegra Faye (Date of defense: 2024-03-21)

Polycomb repressive complexes (PRC1/2) are key chromatin regulators in development. Their deregulation is implicated in various cancers including leukaemia. Meanwhile, MLL-rearrangements by chromosomal translocations and ...

Influencias del entorno alimentario de los centros educativos sobre el peso de los escolares 

Londoño Cañola, Catalina (Date of defense: 2024-03-18)

Esta tesis tiene como objetivos evaluar el entorno alimentario alrededor de las escuelas de Barcelona en términos de proximidad y disponibilidad de establecimientos alimentarios y su relación con el nivel socioeconómico ...

Dinámica clonal en las neoplasias mieloproliferativas crónicas 

Fernández Ibarrondo, Lierni (Date of defense: 2024-04-05)

Las neoplasias mieloproliferativas Philadelphia-negativas son enfermedades clonales que se originan en las células madre hematopoyéticas, ocasionadas por la adquisición de mutaciones driver que afectan a la vía JAK/STAT. ...

Precise writing of human genomes: engineering & characterizing genome editors for programmable DNA integration in human cells 

Ivancic, Dimitrie (Date of defense: 2024-04-03)

Methods for genome engineering have enabled construction of synthetic genomes, therapeutically reprogrammed cells, synthetic organs, and modification of human genomes. Design and discovery of genome editors has enabled ...

Neural entrainment to languages of different rhythms in adults and infants 

Özer, Ege Ekin (Date of defense: 2024-03-21)

In this thesis, we explored neural entrainment as a potential mechanism to underline the behavioral evidence that certain phonological properties of listeners’ native language affects speech segmentation. In two experimental ...

Analysis of circulating RNAs for the early detection of complex diseases using liquid biopsy 

Cabús, Lluc (Date of defense: 2024-03-15)

RNA is a molecule that is released by the different tissues into the circulation. When it is found in the circulation it is called cell-free RNA (cfRNA). This type of molecule has great potential as a noninvasive biomarker ...

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