Universitat Pompeu Fabra
Now showing items 3112-3131 of 3232
Understanding how receptor-ligand interactions occur is a first step towards designing new drugs. The complete reconstruction of the binding process in a drug-receptor system provides all the physical-chemistry variables ...
Three microtubule (MT) assembly pathways participate in the assembly of the bipolar spindle: the centrosomal pathway, the augmin dependent amplification pathway and the RanGTP/chromosome dependent pathway. To form the ...
Rearrangements involving the mixed lineage leukemia gene (MLL) are found in majority of human infant leukemias (>60% of ALLs, 35% of AMLs) and are associated with dismal prognosis of these patients. They are also found in ...
Advanced societies have witnessed unprecedented socioeconomic and technological changes in the last 50 years. The growth of the service sector has transformed the class structure, and social mobility has increased for ...
The three chapters included in this dissertation aim to improve our understanding of the distance between people's desires regarding the timing and the number of children they want to have and what they finally achieve. ...
Cancer is a disease of the genome. The study of tumor genomic alterations is used to guide several precision medicine strategies, some approved and a large number under clinical development. On the other hand, the study ...
La aplicación de la radiación ionizante (RI) en ámbito médico ha llegado, sin duda, para salvar vidas. Sin embargo, hay una preocupación entre los expertos de salud pública y protección radiológica con relación al incremento ...
Los inhibidores de PARP han surgido como nuevas terapias basadas en el papel essencial de las Poly (ADP-ribosa) polimerasas PARP-1 y PARP-2 en la respuesta a daño en el DNA, explotando el efecto de las mismas en la célula ...
Aquesta tesi investiga els mecanismes de formació i evolució de gens de novo utilitzant seqüenciació massiva de transcrits complerts i de fragments protegits per ribosomes. Hem identificat milers de gens de novo en humans ...
The local translation of messenger RNAs (mRNAs) within different neuronal compartments is a prerequisite the formation of long-term memories. mRNAs are localized via active transport along microtubules, however, the ...
This thesis is focused on the nationalization of party systems in Western Europe and combines four different approaches. Despite the literature claiming that political decentralization reduces party system nationalization, ...
The purpose of this dissertation is to systematically investigate the theoretical perspective that political power derives from socioeconomic power—a fundamental tenet of both sociological theories of assimilation and ...
Background: There is evidence suggesting that body weight is associated with lung function, but results are contradictory and suffer from important limitations. We aimed to assess the association of body weight and composition ...
To ensure faithful segregation of the genetic material, cells build the mitotic spindle, a machinery made of dynamic microtubules (MTs) and MT associated proteins (MAPs). Chromosome bi-orientation is achieved through the ...
The present research is aimed at analyzing how human’s brain jointly computes cognitive and social interactions in presence of implicit social stimuli and/or in presence of socially neutral stimuli. First we analyzed the ...
Widespread transcription in mammals revealed unexpected discovery of non-coding elements like long noncoding RNAs (lncRNAs) and repetitive elements. First, lncRNAs were previously identified in limited number of tissues ...
The existence of transportation costs gives labor markets a local dimension. In particular, the well-documented existence of agglomeration economies creates a positive correlation between a city's size and the productivity ...
Esta tesis estudia la especificidad de los significados léxicos especializados, a partir del análisis del funcionamiento de nombres relacionales; ofrece una explicación integrada de la semántica especializada y no especializada ...
El objetivo de esta Tesis doctoral es identificar las unidades de conocimiento especializado del derecho de extranjería con el fin de representar la relación de la equivalencia en un diccionario bilingüe español-rumano ...
