Universitat Pompeu Fabra
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Esta tesis doctoral tiene como finalidad principal analizar la situación de la enseñanza de la lengua china en España, concretamente en Barcelona, y en toda su complejidad, para proponer la introducción de léxico ...
Metastasis is the major cause of death from Breast Cancer (BCa). During its progression, divergent opinions have arisen regarding the hormonal status of the BCa subtypes. The mammary gland is composed of different cell ...
Translation control is a vital aspect of gene expression for both viruses and their cellular hosts. We have previously shown that the cellular mRNA decay activators Dhh1 and Lsm1-7 promote translation of positive-strand ...
G protein-coupled receptors (GPCRs) are the main acceptors of neurotransmitters, and thus play an important role in communication between neurons. Because of this they are an attractive drug target for multiple neurodegenerative ...
Caenorhabditis elegans provides a powerful experimental system for understanding fundamental questions in biomedical research, including the consequences of pre-mRNA splicing alterations. Here, we have applied CRISPR and ...
The calcineurin-NFATc signaling pathway is involved in many aspects of the development and function of the immune, neural, skeletal, cardiovascular and muscular system of vertebrates. Regulators of Calcineurin (RCAN) ...
To ensure faithful segregation of the genetic material, during mitosis the cell assembles the mitotic spindle, a macromolecular machine made of dynamic microtubules and associated proteins. Spindle microtubules are assembled ...
Numerous studies have shown that the protein kinase IKKα is associated with cancer progression and metastasis in different models. However, the mechanisms underlying IKKα tumorigenic functions are poorly understood. We ...
The presence of an extra copy of Human Chromosome 21 (HSA21) in Down syndrome (DS) is one of the most complex genetic perturbations compatible with life and is the most common genetic cause of intellectual disability. Here, ...
Environmental stress is a major aspect of life and a limiting factor for the survival and distribution of species. Understanding the organismal stress response and the developed coping mechanisms is indispensable in order ...
Microexons are an unusual form of alternative splicing with high evolutionary conservation, however, their functions are still far from being understood. In this thesis, we focused on a neuronal-specific microexon that ...
This doctoral work focuses on identifying and understanding the intents that motivate a user to perform a search on the Web. To this end, we apply machine learning models that do not require more information than the one ...
This thesis studies parametric optimization in cellular and cell-free networks, exploring data-based and expert-based paradigms. Power allocation and power control, which adjust the transmit power to meet different fairness ...
La organización del genoma en células mamíferas sigue siendo en gran parte desconocida. Un nivel fundamental de organización se considera el bucle de cromatina, que consiste en una región de ADN atrapada en el interior ...
Opisthokonta is an eukaryotic supergroup that contains Metazoa, Fungi and their unicellular relatives. Therefore, this group provides an ideal framework to study distinct unicellular-multicellular transitions, among them, ...
Precise regulation of neurogenesis is achieved by differentially allocating the neurogenic competence along the tissue. In the hindbrain proneural gene expression is stereotypically confined in segment boundary-adjacent ...
The generation of cell diversity in the embryonic brain relies on the balance between cell proliferation and differentiation. The hindbrain boundary cells specify at the interface between adjacent compartments. Boundary ...
Understanding the determinants of childhood obesity has never been more urgent given the high levels across the world. It is increasingly recognized that the urban environment may affect childhood growth and obesity, and ...
Urban environments are very complex systems with a myriad of factors intricately related. Built environment, transport, physical activity and sedentary behaviours, air pollution, and social contacts and feelings of loneliness ...
Urban design influences how we go about our lives and even how we feel about our neighbors. Using data from the Copernicus Urban Atlas, I find that residents of cities across Europe that have more continuous urban fabric ...
