Now showing items 3168-3187 of 3292
Mandage, Rajendra (Date of defense: 2018-01-12)
The EBV has been linked to multiple human disease phenotypes and has been associated with cancers and other infections. Recently single gene analysis and genome-wide analysis studies have been exploited to uncover the human ...
Ferruz Capapey, Noelia (Date of defense: 2016-03-04)
Understanding how receptor-ligand interactions occur is a first step towards designing new drugs. The complete reconstruction of the binding process in a drug-receptor system provides all the physical-chemistry variables ...
Rosas Salvans, Miquel (Date of defense: 2017-12-19)
Three microtubule (MT) assembly pathways participate in the assembly of the bipolar spindle: the centrosomal pathway, the augmin dependent amplification pathway and the RanGTP/chromosome dependent pathway. To form the ...
Sinha, Roshani (Date of defense: 2016-12-16)
Rearrangements involving the mixed lineage leukemia gene (MLL) are found in majority of human infant leukemias (>60% of ALLs, 35% of AMLs) and are associated with dismal prognosis of these patients. They are also found in ...
Ağlamaz, Fatma Sibel (Date of defense: 2021-06-29)
Advanced societies have witnessed unprecedented socioeconomic and technological changes in the last 50 years. The growth of the service sector has transformed the class structure, and social mobility has increased for ...
Ciganda, Daniel (Date of defense: 2017-01-31)
The three chapters included in this dissertation aim to improve our understanding of the distance between people's desires regarding the timing and the number of children they want to have and what they finally achieve. ...
Rubio Pérez, Carlota (Date of defense: 2017-11-28)
Cancer is a disease of the genome. The study of tumor genomic alterations is used to guide several precision medicine strategies, some approved and a large number under clinical development. On the other hand, the study ...
Pasqual, Elisa (Date of defense: 2019-12-03)
La aplicación de la radiación ionizante (RI) en ámbito médico ha llegado, sin duda, para salvar vidas. Sin embargo, hay una preocupación entre los expertos de salud pública y protección radiológica con relación al incremento ...
Moreno Lama, Lucía (Date of defense: 2020-01-16)
Los inhibidores de PARP han surgido como nuevas terapias basadas en el papel essencial de las Poly (ADP-ribosa) polimerasas PARP-1 y PARP-2 en la respuesta a daño en el DNA, explotando el efecto de las mismas en la célula ...
Ruiz Orera, Jorge (Date of defense: 2017-01-19)
Aquesta tesi investiga els mecanismes de formació i evolució de gens de novo utilitzant seqüenciació massiva de transcrits complerts i de fragments protegits per ribosomes. Hem identificat milers de gens de novo en humans ...
Grawenhoff, Julia (Date of defense: 2024-01-24)
The local translation of messenger RNAs (mRNAs) within different neuronal compartments is a prerequisite the formation of long-term memories. mRNAs are localized via active transport along microtubules, however, the ...
D'Altri, Teresa (Date of defense: 2013-07-26)
Simón Cosano, Pablo (Date of defense: 2011-11-03)
This thesis is focused on the nationalization of party systems in Western Europe and combines four different approaches. Despite the literature claiming that political decentralization reduces party system nationalization, ...
Nguyen, My Land Do (Date of defense: 2020-01-31)
The purpose of this dissertation is to systematically investigate the theoretical perspective that political power derives from socioeconomic power—a fundamental tenet of both sociological theories of assimilation and ...
Prado Peralta, María Gabriela (Date of defense: 2020-07-14)
Background: There is evidence suggesting that body weight is associated with lung function, but results are contradictory and suffer from important limitations. We aimed to assess the association of body weight and composition ...
Zadra, Ivan (Date of defense: 2022-03-17)
To ensure faithful segregation of the genetic material, cells build the mitotic spindle, a machinery made of dynamic microtubules (MTs) and MT associated proteins (MAPs). Chromosome bi-orientation is achieved through the ...
Santamaría-García, Hernando (Date of defense: 2014-01-31)
The present research is aimed at analyzing how human’s brain jointly computes cognitive and social interactions in presence of implicit social stimuli and/or in presence of socially neutral stimuli. First we analyzed the ...
Bogu, Gireesh K. (Date of defense: 2017-01-13)
Widespread transcription in mammals revealed unexpected discovery of non-coding elements like long noncoding RNAs (lncRNAs) and repetitive elements. First, lncRNAs were previously identified in limited number of tissues ...
Morron Salmeron, Adrià (Date of defense: 2017-05-30)
The existence of transportation costs gives labor markets a local dimension. In particular, the well-documented existence of agglomeration economies creates a positive correlation between a city's size and the productivity ...
Adelstein, Andreina (Date of defense: 2007-02-16)
Esta tesis estudia la especificidad de los significados léxicos especializados, a partir del análisis del funcionamiento de nombres relacionales; ofrece una explicación integrada de la semántica especializada y no especializada ...