Now showing items 449-468 of 3213

    Computational analysis of ribonucleoprotein networks 

    Vandelli, Andrea (Date of defense: 2023-04-19)

    Ribonucleoprotein condensates such as stress granules (SGs) and processing bodies (PBs) form in response to specific stimuli in the cell. Even though the key protein and RNA elements of these condensates are starting to ...

    Computational anatomy as a driver of understanding structural and functional cardiac remodeling 

    Bernardino, Gabriel (Date of defense: 2019-12-16)

    We present a statistical shape analysis framework to identify cardiac shape remodelling while accounting for individual´s natural variability and apply it in two clinical applications: comparing triathletes with controls, ...

    Computational approaches and resources to support translational research in human diseases 

    Piñero González, Janet (Date of defense: 2015-12-17)

    In the last two decades, the volume and variety of biomedical data has dramatically increased. The data is heterogeneous and scattered across many resources. This produces bottlenecks in the analysis and extraction of ...

    Computational approaches for integrative cancer genomics 

    Pérez Llamas, Christian (Date of defense: 2015-12-18)

    Given the complexity and heterogeneity of cancer, the development of new high-throughput wide-genome technologies has open new possibilities for its study. Several projects around the globe are exploiting these technologies ...

    Computational approaches for melodic description in indian art music corpora 

    Gulati, Sankalp (Date of defense: 2016-11-17)

    Automatically describing contents of recorded music is crucial for interacting with large volumes of audio recordings, and for developing novel tools to facilitate music pedagogy. Melody is a fundamental facet in most music ...

    Computational approaches to characterize RNP granules 

    Cid Samper, Fernando (Date of defense: 2020-01-27)

    Ribonucleoprotein granules (RNP granules) are liquid-liquid phase separated complexes composed mainly by proteins and RNA. They are responsible of many processes involved in RNA regulation. Alterations in the dynamics ...

    Computational approaches to the modelling of topological and dynamical aspects of biochemical networks 

    López García de Lomana, Adrián (Date of defense: 2010-10-19)

    Els mecanismes de regulaci o de les c el lules poden ser modelats per controlar i entendre la biologia cel lular. Diferents nivells d'abstracci o s'utilitzen per descriure els processos biol ogics. En aquest treball ...

    Computational characterization of protein-RNA interactions and implications for phase separation 

    Armaos, Alexandros (Date of defense: 2020-01-23)

    Despite what was previously considered, the role of RNA is not only to carry the genetic information from DNA to proteins. Indeed, RNA has proven to be implicated in more complex cellular processes. Recent evidence ...

    Computational engineering of biomolecules 

    Cianferoni, Damiano (Date of defense: 2023-10-09)

    Aquesta tesi presenta diversos avenços que inclouen: (i) noves funcionalitats afegides a la “suite” d'eines de disseny de proteïnes FoldX per permetre als usuaris treballar amb qualsevol tipus de molècula; (ii) estudis ...

    Computational fluid simulations in clinical datasets for understanding thrombus formation before and after left atrial appendage occlusion 

    Mill Tena, Jordi (Date of defense: 2022-10-14)

    Atrial fibrillation is considered the most common arrhythmia in humans. Because the left atrium of the heart stops beating properly and begins to do so in an arrhythmic manner, the blood may become stagnant in a small ...

    Computational genomics of selenoproteins 

    Mariotti, Marco (Date of defense: 2013-12-13)

    Selenoproteins are a diverse class of proteins containing selenocysteine, the 21st aminoacid. Selenocysteine is inserted co-translationally, recoding very specific UGA codons through a dedicated machinery. Standard gene ...

    Computational identification of genes: ab initio and comparative approaches 

    Parra Farré, Genís (Date of defense: 2004-12-03)

    El trabajo que aquí se presenta, estudia el reconocimiento de las señales que delimitan y definen los genes que codifican para proteínas, así como su aplicabilidad en los programas de predicción de genes. La tesis que aquí ...

    Computational image analysis methods for the study of perinatal brain development 

    Urru, Andrea (Date of defense: 2022-07-28)

    Perinatal medicine has drawn increasing attention by the neuroscientific research community, as an early detection of most pathologies leads to more effective therapies and treatments. Monitoring fetal and neonatal brain ...

    A Computational model for generating and analysing architectural layouts in virtual environments 

    Bahrehmand, Arash (Date of defense: 2016-09-16)

    Designing interior layouts is one of the most common elements of the immersive computer graphics projects (e.g., games, virtual reality and special effects). The design of 3D virtual environments aims to provide not only ...

    Computational modeling of user activity in full-body interaction environments for ASC children: multimodal analysis of social interaction behaviors through psychophysiology, system activity, video coding, questionnaires, and body cues 

    Sayis, Batuhan (Date of defense: 2021-05-04)

    Full-body Interaction experiences based on Mixed Reality (MR) systems are already playing an important role in encouraging socialization behaviors in children with Autism Spectrum Condition (ASC), as seen in the state of ...

    Computational modelling of expressive music performance in jazz guitar: a machine learning approach 

    Giraldo, Sergio Iván (Date of defense: 2016-09-16)

    Computational modelling of expressive music performance deals with the analysis and characterization of performance deviations from the score that a musician may introduce when playing a piece in order to add expression. ...

    Computational models of the heart for planning and treatment of outflow tract ventricular arrhythmias 

    Doste Beltrán, Rubén (Date of defense: 2019-11-18)

    The purpose of this thesis was to develop personalised cardiovascular therapy guided by multimodal noninvasive imaging and simulations, combined with artificial intelligence tools, for the management of the outflow tract ...

    Computational studies of DNA damage and repair of alkylating agents and UV light 

    Kranas, Hanna (Date of defense: 2023-11-03)

    Living cells are exposed to naturally occurring DNA-damaging agents that promote the loss of genome integrity, threatening the proper functioning of the cell. To counteract the toxic accumulation of DNA damage, organisms ...

    Computational studies of DNA modifications and mutations in bulk and single-cell data 

    Bonet Giner, Jose (Date of defense: 2022-06-03)

    Sequencing technologies have recently evolved and generated large amounts of data. These datasets have had significant impacts in the cancer field and the detection of damage and repair mechanisms. Methodologies to analyze ...

    Computational study of cancer 

    Gundem, Gunes (Date of defense: 2011-09-29)

    In my thesis, I focused on integrative analysis of high-throughput oncogenomic data. This was done in two parts: In the first part, I describe IntOGen, an integrative data mining tool for the study of cancer. This system ...