Acquired resistance to the anti-EFGR monoclonal antibody cetuximab in colorectal cancer 

Dalmases Massegú, Alba (Date of defense: 2012-06-22)

EGFR is a transmembrane tyrosine kinase receptor from the HER family which, upon ligand stimulation, activates different signaling pathways involved in tumorogenesis. EGFR can be targeted by monoclonal antibodies, as ...